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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1990764
Molecular formulaC25H16ClN3O
IUPAC name2-[5-chloro-2-(9H-fluoren-9-yl)-3-oxopyridazin-4-yl]-2-phenylacetonitrile
Molecular weight409.873
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP4.6
SynonymsSR-02000001656
SR-02000001656-1
Inchi KeyBWFJRRVNUQTGTA-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H16ClN3O/c26-22-15-28-29(25(30)23(22)21(14-27)16-8-2-1-3-9-16)24-19-12-6-4-10-17(19)18-11-5-7-13-20(18)24/h1-13,15,21,24H
PubChem CID53364423
ChEMBLCHEMBL1990764
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC502220.0 nMPubChem BioAssay data setChEMBL

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