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Name | Mu-type opioid receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Oprm1 |
Synonym | Opioid receptor B opioid receptor OP3 mu receptor MOR-1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 398 |
Amino acid sequence | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP |
UniProt | P33535 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL270 |
IUPHAR | 319 |
DrugBank | N/A |
Name | Leu-enkephalin |
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Molecular formula | C28H37N5O7 |
IUPAC name | (2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-azaniumyl-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoate |
Molecular weight | 555.632 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 6 |
XlogP | -0.5 |
Synonyms | N/A |
Inchi Key | URLZCHNOLZSCCA-VABKMULXSA-N |
Inchi ID | InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1 |
PubChem CID | 124081685 |
ChEMBL | CHEMBL8234 |
IUPHAR | N/A |
BindingDB | 50001465 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 49.8 nM | PMID6296388 | ChEMBL |
IC50 | 50.0 nM | PMID6296388 | BindingDB |
Ki | 1.22 nM | PMID2537427 | BindingDB |
Ki | 2.21 nM | PMID6296388 | BindingDB |
Ki | 2.4 nM | PMID11212102 | BindingDB |
Ki | 2.42 nM | PMID11212102 | ChEMBL |
Ki | 2.53 nM | PMID10691681 | ChEMBL |
Ki | 9.4 nM | PMID10479285, PMID2536436, PMID8230106, PMID8164255, PMID1331451 | BindingDB |
Ki | 9.43 nM | PMID2536436, PMID1331451, PMID2999401, PMID20218625, PMID10479285, PMID2537427, PMID8164255, PMID8230106 | ChEMBL |
Ki | 9.6 nM | PMID2999401 | BindingDB |
Ki | 24.0 nM | PMID12372527 | BindingDB,ChEMBL |
Ki | 27.7 nM | PMID6296388 | ChEMBL |
Potency | 1.0 - | PMID8230106 | ChEMBL |
Potency ratio | 1.0 - | PMID2999401 | ChEMBL |
Ratio | 3.73 - | PMID10479285 | ChEMBL |
Relative potency | 1.0 - | PMID10479285, PMID2537427, PMID8164255, PMID1331451 | ChEMBL |
SR | 1.69 - | PMID11212102 | ChEMBL |
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