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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Rattus norvegicus (Rat)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProt	P46002
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4127
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL367673
Molecular formula	C25H27N5O4
IUPAC name	methyl 1-(dimethylcarbamoyl)-3-[5-(2-methylimidazo[4,5-c]pyridin-1-yl)pentanoyl]indole-4-carboxylate
Molecular weight	461.522
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	2.6
Synonyms	1-Dimethylcarbamoyl-3-[5-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-pentanoyl]-1H-indole-4-carboxylic acid methyl ester BDBM50062087
Inchi Key	BWCKENYUNOPLFF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H27N5O4/c1-16-27-19-14-26-12-11-20(19)29(16)13-6-5-10-22(31)18-15-30(25(33)28(2)3)21-9-7-8-17(23(18)21)24(32)34-4/h7-9,11-12,14-15H,5-6,10,13H2,1-4H3
PubChem CID	10671691
ChEMBL	CHEMBL367673
IUPHAR	N/A
BindingDB	50062087
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	<1.0 mg.kg-1	PMID9438024	ChEMBL

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