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GPCR

Name	Alpha-1D adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1d
Synonym	ADRA1A Gpcr8 Adra-1 alpha1D-AR alpha1D-adrenoceptor alpha1a/d-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-1D adrenoreceptor Alpha-1D adrenoceptor ADRA1 Alpha-1A adrenergic receptor alpha 1D-adrenoreceptor alpha 1D-adrenoceptor adrenergic receptor delta1 Adrd1 ADRA1R RA42 [ Show all ]
Disease	N/A for non-human GPCRs
Length	561
Amino acid sequence	MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
UniProt	P23944
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL326
IUPHAR	24
DrugBank	N/A

Ligand

Name	CHEMBL417954
Molecular formula	C19H21F5N4O3
IUPAC name	5-fluoro-3-[3-[4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl]propyl]-1H-pyrimidine-2,4-dione
Molecular weight	448.394
Hydrogen bond acceptor	10
Hydrogen bond donor	1
XlogP	2.7
Synonyms	BDBM50220788 3-[3-[4-[2-(2,2,2-Trifluoroethoxy)-4-fluorophenyl]piperazino]propyl]-5-fluorouracil
Inchi Key	BVVTZMMHKZWLED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21F5N4O3/c20-13-2-3-15(16(10-13)31-12-19(22,23)24)27-8-6-26(7-9-27)4-1-5-28-17(29)14(21)11-25-18(28)30/h2-3,10-11H,1,4-9,12H2,(H,25,30)
PubChem CID	44298650
ChEMBL	CHEMBL417954
IUPHAR	N/A
BindingDB	50220788
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pA2/pKB	7.1 -	PMID12749888	ChEMBL

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