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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL292729
Molecular formula	C21H25N3O
IUPAC name	N-(9-ethylcarbazol-3-yl)-3-pyrrolidin-1-ylpropanamide
Molecular weight	335.451
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.3
Synonyms	SCHEMBL4725105 BDBM50128939 N-(9-Ethyl-9H-carbazol-3-yl)-3-pyrrolidin-1-yl-propionamide
Inchi Key	BVLRPFAPSIXVLV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H25N3O/c1-2-24-19-8-4-3-7-17(19)18-15-16(9-10-20(18)24)22-21(25)11-14-23-12-5-6-13-23/h3-4,7-10,15H,2,5-6,11-14H2,1H3,(H,22,25)
PubChem CID	22458796
ChEMBL	CHEMBL292729
IUPHAR	N/A
BindingDB	50128939
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	11.0 nM	PMID12781180	BindingDB,ChEMBL

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