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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	4-Methylhistamine
Molecular formula	C6H11N3
IUPAC name	2-(5-methyl-1H-imidazol-4-yl)ethanamine
Molecular weight	125.175
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	-0.2
Synonyms	5(4)-Methylhistamine Dihydrochloride AKOS012036768 LS-78033 SCHEMBL11452941 1H-Imidazole-4-ethanamine, 5-methyl- 2-(5-Methyl-4-imidazolyl)ethylamine Dihydrochloride 36507-31-0 5-Methyl-1H-imidazole-4-ethanamine Hydrochloride AN-9442 EN300-82322 MolPort-006-803-984 UNII-54ST71P9EE 2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine AB45417 C17929 IMIDAZOLE, 4-(2-AMINOETHYL)-5-METHYL- PDSP2_000398 2-(5-METHYL-3H-IMIDAZOL-4-YL)-ETHYLAMINE 5-(2-Aminoethyl)-4-methylimidazole AKOS022477289 CHEMBL275443 MCULE-8926131767 SCHEMBL606803 2-(4-METHYL-1H-IMIDAZOL-5-YL)ETHAN-1-AMINE 4-Methyl Histamine Dihydrochloride 5-Methylhistamine BDBM22880 FT-0736440 p-methylhistamine ZINC3605034 2-(5-methyl-1H-imidazol-4-yl)ethanamine 5(4)-Methylhistamine AC1L1XS2 CHEBI:74760 L000072 SC-51140 1H-Imidazo-4-ethanamine, 5-methyl- 2-(5-Methyl-4-imidazolyl)ethylamine 5-Methyl-1H-imidazole-4-ethanamine ALBB-030504 D02SQF Methylhistamine-4 UGYXPZQILZRKJJ-UHFFFAOYSA-N 2-(4-METHYL-1H-IMIDAZOL-5-YL)ETHANAMINE 36376-47-3 (di-hydrochloride) 4-Methyl-1H-imidazole-5-ethanamine 54ST71P9EE BRD-K70821460-300-01-6 GTPL1269 PDSP1_000400 2-(5-Methyl-1H-imidazol-4-yl)ethylamine # [ Show all ]
Inchi Key	UGYXPZQILZRKJJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H11N3/c1-5-6(2-3-7)9-4-8-5/h4H,2-3,7H2,1H3,(H,8,9)
PubChem CID	37463
ChEMBL	CHEMBL275443
IUPHAR	1269
BindingDB	22880
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	43.0 -	PMID1967317	ChEMBL
Ki	<10000.0 nM	PMID6135157	PDSP,BindingDB

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