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GPCR

Name	Histamine H1 receptor
Species	Homo sapiens (Human)
Gene	HRH1
Synonym	HH1R H1R Hisr H1 receptor
Disease	Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder Insomnia Hypersensitivity reactions; Coughs; Common colds Pain Parkinson's disease Perennial and seasonal allergic rhinitis; Vasomotor rhinitis; Allergic conjunctivitis Vertigo meniere's disease Unspecified Sleep disorders Seasonal and perennial allergic rhinitis and vasomotor rhinitis Rhinitis; Urticaria; Allergy Rhinitis Respiratory disease Respiratory allergies; Cancer Respiratory allergies; Allergic rhinitis Pruritus Nasal congestion Hay fever; Cough Hay fever; Allergic rhinitis Anxiety disorder Anesthesia Allergy Allergic skin disorders Allergic rhinitis; Urticaria; Pruritus Allergic rhinitis; Urticaria Allergic rhinitis Allergic disorders; Itching; Nausea Allergic conjunctivitis Anxiety disorder; Morning sickness Asthma Hay fever Common cold; Allergies Depression Dry cough [ Show all ]
Length	487
Amino acid sequence	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
UniProt	P35367
Protein Data Bank	3rze
GPCR-HGmod model	P35367
3D structure model	This structure is from PDB ID 3rze.
BioLiP	BL0202178, BL0202179, BL0202180
Therapeutic Target Database	T77913
ChEMBL	CHEMBL231
IUPHAR	262
DrugBank	BE0000442

Ligand

Name	4-Methylhistamine
Molecular formula	C6H11N3
IUPAC name	2-(5-methyl-1H-imidazol-4-yl)ethanamine
Molecular weight	125.175
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	-0.2
Synonyms	2-(5-Methyl-4-imidazolyl)ethylamine 5(4)-Methylhistamine AC1L1XS2 CHEBI:74760 L000072 SC-51140 1H-Imidazo-4-ethanamine, 5-methyl- 36376-47-3 (di-hydrochloride) 5-Methyl-1H-imidazole-4-ethanamine ALBB-030504 D02SQF Methylhistamine-4 UGYXPZQILZRKJJ-UHFFFAOYSA-N 2-(4-METHYL-1H-IMIDAZOL-5-YL)ETHANAMINE 2-(5-Methyl-1H-imidazol-4-yl)ethylamine # 4-Methyl-1H-imidazole-5-ethanamine 54ST71P9EE BRD-K70821460-300-01-6 GTPL1269 PDSP1_000400 2-(5-Methyl-4-imidazolyl)ethylamine Dihydrochloride 5(4)-Methylhistamine Dihydrochloride AKOS012036768 LS-78033 SCHEMBL11452941 1H-Imidazole-4-ethanamine, 5-methyl- 36507-31-0 5-Methyl-1H-imidazole-4-ethanamine Hydrochloride AN-9442 EN300-82322 MolPort-006-803-984 UNII-54ST71P9EE 2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine 2-(5-METHYL-3H-IMIDAZOL-4-YL)-ETHYLAMINE AB45417 C17929 IMIDAZOLE, 4-(2-AMINOETHYL)-5-METHYL- PDSP2_000398 5-(2-Aminoethyl)-4-methylimidazole AKOS022477289 CHEMBL275443 MCULE-8926131767 SCHEMBL606803 2-(4-METHYL-1H-IMIDAZOL-5-YL)ETHAN-1-AMINE 4-Methyl Histamine Dihydrochloride 5-Methylhistamine BDBM22880 FT-0736440 p-methylhistamine ZINC3605034 2-(5-methyl-1H-imidazol-4-yl)ethanamine [ Show all ]
Inchi Key	UGYXPZQILZRKJJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H11N3/c1-5-6(2-3-7)9-4-8-5/h4H,2-3,7H2,1H3,(H,8,9)
PubChem CID	37463
ChEMBL	CHEMBL275443
IUPHAR	1269
BindingDB	22880
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	15848.9 nM	PMID19791743	BindingDB,ChEMBL
Intrinsic activity	0.9 -	PMID21044842, PMID27007611	ChEMBL

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