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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanocortin receptor 5
Species	Homo sapiens (Human)
Gene	MC5R
Synonym	melanocortin receptor 5 MC5R MC5-R MC5 receptor MC-2
Disease	Acne vulgaris Seborrhea
Length	325
Amino acid sequence	MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
UniProt	P33032
Protein Data Bank	N/A
GPCR-HGmod model	P33032
3D structure model	This predicted structure model is from GPCR-EXP P33032.
BioLiP	N/A
Therapeutic Target Database	T95302
ChEMBL	CHEMBL4608
IUPHAR	286
DrugBank	N/A

Ligand

Name	CHEMBL366036
Molecular formula	C27H35Cl2N5O
IUPAC name	4-[[C-(4-aminopiperidin-1-yl)-N-cyclohexylcarbonimidoyl]amino]-N-[2-(2,4-dichlorophenyl)ethyl]benzamide
Molecular weight	516.511
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	5.1
Synonyms	BDBM50150832 4-[(4-Amino-N-cyclohexyl-piperidine-1-carboximidoyl)-amino]-N-[2-(2,4-dichloro-phenyl)-ethyl]-benzamide
Inchi Key	BVEADRMJYJGDGL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H35Cl2N5O/c28-21-9-6-19(25(29)18-21)12-15-31-26(35)20-7-10-24(11-8-20)33-27(32-23-4-2-1-3-5-23)34-16-13-22(30)14-17-34/h6-11,18,22-23H,1-5,12-17,30H2,(H,31,35)(H,32,33)
PubChem CID	11785639
ChEMBL	CHEMBL366036
IUPHAR	N/A
BindingDB	50150832
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	230.0 nM	PMID15267247	BindingDB,ChEMBL

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