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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Follicle-stimulating hormone receptor
Species	Homo sapiens (Human)
Gene	FSHR
Synonym	Follitropin receptor FSH receptor FSH-R LGR1
Disease	Female infertility African trypanosomiasis Contraception Ovarian cancer
Length	695
Amino acid sequence	MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
UniProt	P23945
Protein Data Bank	4mqw
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4mqw.
BioLiP	BL0274372
Therapeutic Target Database	T68334
ChEMBL	CHEMBL2024
IUPHAR	N/A
DrugBank	BE0000387

Ligand

Name	CHEMBL3263689
Molecular formula	C29H33N5O5
IUPAC name	N-[2-[4-(2-methylphenyl)piperazin-1-yl]-5-[3-(2-oxo-1,3-oxazolidin-3-yl)propylcarbamoyl]phenyl]furan-2-carboxamide
Molecular weight	531.613
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	3.5
Synonyms	BDBM50012118 SCHEMBL14651689
Inchi Key	UFGIWRWUBRNOCQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H33N5O5/c1-21-6-2-3-7-24(21)32-13-15-33(16-14-32)25-10-9-22(20-23(25)31-28(36)26-8-4-18-38-26)27(35)30-11-5-12-34-17-19-39-29(34)37/h2-4,6-10,18,20H,5,11-17,19H2,1H3,(H,30,35)(H,31,36)
PubChem CID	71234037
ChEMBL	CHEMBL3263689
IUPHAR	N/A
BindingDB	50012118
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	28000.0 nM	PMID24685543	BindingDB,ChEMBL

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