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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Homo sapiens (Human)
Gene	HTR1D
Synonym	Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D 5-HT-1D-alpha 5-HT1D 5-HT1D receptor 5-HT1Dalpha 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Gpcr14 HT1DA [ Show all ]
Disease	Acute migraine Epilepsy Migraine headaches Mood disorder Migraine Major depressive disorder Severe mood disorders [ Show all ]
Length	377
Amino acid sequence	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
UniProt	P28221
Protein Data Bank	N/A
GPCR-HGmod model	P28221
3D structure model	This predicted structure model is from GPCR-EXP P28221.
BioLiP	N/A
Therapeutic Target Database	T11072
ChEMBL	CHEMBL1983
IUPHAR	3
DrugBank	BE0000659

Ligand

Name	mianserin
Molecular formula	C18H20N2
IUPAC name	5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene
Molecular weight	264.372
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.4
Synonyms	Prestwick3_000099 BRD-A19661776-003-05-2 Spectrum5_001772 CHEBI:51137 X5019 Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl- FT-0697022 KBio2_004869 LS-61197 Mianserine NCGC00015656-06 5-methyl-2,5-diazatetracyclo[13.4.0.0;{2,7}.0;{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene Norval AN-15691 Biomol-NT_000135 SPBio_000986 BSPBio_000058 Tolvin (TN) CS-2078 DSSTox_CID_3317 HSDB 7182 KBioGR_001820 mianserin a Mianserinum [INN-Latin] NCGC00015656-10 78684-63-6 PDSP1_001532 Prestwick1_000099 BPBio1_000331 Spectrum3_001836 CAS-24219-97-4 Tox21_110191_1 DTXSID6023317 KBio1_000844 Lerivon Mianserina NCGC00015656-04 21535-47-7 (mono-hydrochloride) NCGC00024926-04 AKOS005216268 SBI-0050722.P003 BRD-A19661776-003-16-9 Spectrum_001810 Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl- GTPL135 KBio2_007437 Mianserine [INN-French] 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine NCGC00015656-08 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene Norval (TN) API0000656 Bolvidon (TN) SPBio_001997 BSPBio_003511 Tolvon (TN) D08216 DSSTox_GSID_23317 HY-B0188 KBioSS_002303 Mianserin Monohydrochloride Mianseryna 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine NCGC00015656-12 AC-631 PDSP2_001516 Prestwick2_000099 BRD-A19661776-001-01-5 Spectrum4_001260 CCG-204829 UEQUQVLFIPOEMF-UHFFFAOYSA-N DB06148 EINECS 246-088-6 KBio2_002301 Lopac0_000744 Mianserina [INN-Spanish] (+-)-Athymil NCGC00015656-05 24219-97-4 NINDS_000844 AM20041174 SCHEMBL18020 BRN 0755346 Tolvan CHEMBL6437 DivK1c_000844 HMS2089A04 KBio3_003016 Mianserin (INN) Mianserinum 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine NCGC00015656-09 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(19),8,10,12,15,17-hexaene Oprea1_703627 BDBM50222218 BPBio1_000064 Spectrum2_001203 C18H20N2 Tox21_110191 D0R6RO DSSTox_RID_76974 IDI1_000844 L000736 Mianserin [INN:BAN] Mianseryna [Polish] 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine # NCGC00024926-03 AC1L1HLP Prestwick0_000099 [ Show all ]
Inchi Key	UEQUQVLFIPOEMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3
PubChem CID	4184
ChEMBL	CHEMBL6437
IUPHAR	135
BindingDB	N/A
DrugBank	DB06148
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	380.19 nM	PMID11755364, PMID11755365	ChEMBL
Ki	220.0 nM	Peroutka et al., PMID1989	PDSP
Ki	398.0 nM	Waeber et al., PMID1988	PDSP

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