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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	SR-02000000459
Molecular formula	C21H22ClN3O2
IUPAC name	5-chloro-4-[3-(dimethylamino)phenoxy]-2-(4-propan-2-ylphenyl)pyridazin-3-one
Molecular weight	383.876
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.9
Synonyms	5-chloro-4-[3-(dimethylamino)phenoxy]-2-(4-propan-2-ylphenyl)pyridazin-3-one SR-02000000459-1 BDBM75926 5-chloranyl-4-[3-(dimethylamino)phenoxy]-2-(4-propan-2-ylphenyl)pyridazin-3-one cid_46835796 5-chloro-4-[3-(dimethylamino)phenoxy]-2-p-cumenyl-pyridazin-3-one 5-chloro-4-[3-(dimethylamino)phenoxy]-2-(4-propan-2-ylphenyl)-3-pyridazinone CHEMBL1703306 [ Show all ]
Inchi Key	BUWZOXLHDODWGZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H22ClN3O2/c1-14(2)15-8-10-16(11-9-15)25-21(26)20(19(22)13-23-25)27-18-7-5-6-17(12-18)24(3)4/h5-14H,1-4H3
PubChem CID	46835796
ChEMBL	CHEMBL1703306
IUPHAR	N/A
BindingDB	75926
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3100.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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