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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesHomo sapiens (Human)
GeneHTR7
Synonym5-HT-7
Serotonin receptor 7
5-HT-X
5-HT1Y
5-HT7
[ Show all ]
DiseaseSleep disorders
Schizophrenia
Major depressive disorder
Length479
Amino acid sequenceMMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProtP34969
Protein Data BankN/A
GPCR-HGmod modelP34969
3D structure modelThis predicted structure model is from GPCR-EXP P34969.
BioLiPN/A
Therapeutic Target DatabaseT79062
ChEMBLCHEMBL3155
IUPHAR12
DrugBankBE0000650, BE0004862

Ligand

NameCHEMBL316039
Molecular formulaC21H26N4O
IUPAC name2a-[4-(3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl)butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one
Molecular weight350.466
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP2.4
Synonyms2a-[4-(4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridine-5-yl)butyl]-1,2,2a,3,4,5-hexahydrobenzo[cd]indol-2-on
SCHEMBL6423050
Inchi KeyAECKIVMAUDSDRJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H26N4O/c26-20-21(10-4-6-15-5-3-7-17(24-20)19(15)21)9-1-2-11-25-12-8-16-18(13-25)23-14-22-16/h3,5,7,14H,1-2,4,6,8-13H2,(H,22,23)(H,24,26)
PubChem CID18377342
ChEMBLCHEMBL316039
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki562.34 nMPMID12182857ChEMBL

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