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GLASS

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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	memantine
Molecular formula	C12H21N
IUPAC name	3,5-dimethyladamantan-1-amine
Molecular weight	179.307
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	3.3
Synonyms	C13736 Spectrum_000607 D-145 Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl- DRG 0267 Exiba (TN) KBio2_001087 1-amino-3,5-dimethyl adamantane LS-157051 3,5-Dimethyl-1-aminoadamantane hydrochlo Memantine (INN) AB00053600 NCGC00015705-04 AKOS016340748 Prestwick0_000978 BBV-39899297 SCHEMBL13213676 SPBio_002926 CCG-204092 TC-145196 D145 ZERO/006024 DSSTox_GSID_45174 GTPL4253 (3,5-Dimethyl-1-adamantyl)amine KBio3_001926 1-Amino-3,5-dimethyladamantane Memantina 3,5-dimethyladamantanylamine Memantine [INN] AB00053600_15 NCGC00015705-09 ANW-56451 Prestwick3_000978 BPBio1_001117 Spectrum4_001022 CTK6B3298 Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl- DivK1c_000068 Ebixa IDI1_000068 1,3-Dimethyl-5-adamantanamine KS-000024QT 3,5-Dimethyl-1-adamantylamine Memantine (extended release) 41100-52-1 (Hydrochloride) MolPort-002-041-858 AKOS000113995 NINDS_000068 BB0216388 SBI-0020417.P004 BSPBio_001015 CAS-19982-08-2 ST057652 D01JEU UNII-W8O17SJF3T DS-3152 FCH1198345 KBio2_003655 1-amino-3,5-dimethyl-adamantane MCULE-3726352671 3,5-Dimethyl-adamantan-1-ylamine Memantine ER AB00053600-13 NCGC00015705-05 ALBB-013872 Prestwick1_000978 BDBM50062599 SCHEMBL2688 Spectrum2_001408 CHEBI:64312 Tox21_110199 ZX-AN012621 DSSTox_RID_80723 HMS500D10 (3,5-Dimethyl-1-adamantyl)amine hydrochloride KBioGR_001543 19982-08-2 Memantina [INN-Spanish] 3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine Memantinum AB0212255 NCGC00024782-02 AZ0001-0553 S-1686 BPBio1_001270 BUGYDGFZZOZRHP-UHFFFAOYSA-N Spectrum5_001355 D 145 Tricyclo(3.3.1.13,7)decan-1-amine, 3,5-dimethyl- DMAA [Antiparkinson Agent] EU-0053634 KBio1_000068 1,3-Dimethyl-5-aminoadamantane Lopac0_000861 3,5-Dimethyl-1-aminoadamantane Memantine (extended release), Forest 51052-62-1 NCGC00015705-03 AKOS015953276 Oprea1_480562 BBL000737 SC-45525 CBMicro_020348 STK520682 D08174 W8O17SJF3T DSSTox_CID_25174 FT-0649142 KBio2_006223 1-amino-3,5-dimethyladamantan Memantin 3,5-dimethyladamantan-1-amine Memantine [INN:BAN] AB00053600_14 NCGC00015705-07 alzantin Prestwick2_000978 Biomol-NT_000209 SPBio_001456 Spectrum3_000923 CHEMBL807 Tox21_110199_1 DB01043 DTXSID5045174 HSDB 7327 KBioSS_001087 3,5-Dimethyl-1-adamantanamine 3,5-dimethyltricyclo[3.3.1.1~3,7~]decan-1-amine Memantinum [INN-Latin] AC1L1HB7 NCGC00024782-03 BB 0216388 SBB002574 BR-33967 [ Show all ]
Inchi Key	BUGYDGFZZOZRHP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
PubChem CID	4054
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB01043
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP

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