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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 8
Species	Homo sapiens (Human)
Gene	CCR8
Synonym	GPRCY6 GPR-CY6 CMKBRL2 CKR-L1 ChemR1 Chemokine receptor-like 1 CCR8 CCR-8 CC-CKR-8 CC chemokine receptor CHEMR1 C-C CKR-8 TER1 [ Show all ]
Disease	Psoriasis
Length	355
Amino acid sequence	MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
UniProt	P51685
Protein Data Bank	N/A
GPCR-HGmod model	P51685
3D structure model	This predicted structure model is from GPCR-EXP P51685.
BioLiP	N/A
Therapeutic Target Database	T20575
ChEMBL	CHEMBL4596
IUPHAR	65
DrugBank	N/A

Ligand

Name	CHEMBL380492
Molecular formula	C34H40ClN3O4
IUPAC name	2-[4-[[1-[[3-(2-chlorophenoxy)phenyl]methyl]piperidin-4-yl]carbamoyl]-4-phenylpiperidin-1-yl]-2-methylpropanoic acid
Molecular weight	590.161
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.7
Synonyms	SCHEMBL6506018 2-(4-{1-[3-(2-chloro-phenoxy)-benzyl]-piperidin-4-ylcarbamoyl}-4-phenyl-piperidin-1-yl)-2-methyl-propionic acid BDBM50185912
Inchi Key	TXEFMFGXKKPZEW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H40ClN3O4/c1-33(2,32(40)41)38-21-17-34(18-22-38,26-10-4-3-5-11-26)31(39)36-27-15-19-37(20-16-27)24-25-9-8-12-28(23-25)42-30-14-7-6-13-29(30)35/h3-14,23,27H,15-22,24H2,1-2H3,(H,36,39)(H,40,41)
PubChem CID	11685733
ChEMBL	CHEMBL380492
IUPHAR	N/A
BindingDB	50185912
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4.0 nM	PMID16640325	BindingDB,ChEMBL
Ki	9.0 nM	PMID16640325	BindingDB,ChEMBL

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