You can:
Name | Proteinase-activated receptor 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | F2R |
Synonym | Coagulation factor II receptor PAR-1 coagulation factor II (thrombin) receptor protease-activated receptor 1 Thrombin receptor [ Show all ] |
Disease | Thrombosis Restenosis Myocardial infarction Cancer Atherosclerosis [ Show all ] |
Length | 425 |
Amino acid sequence | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT |
UniProt | P25116 |
Protein Data Bank | 3vw7 |
GPCR-HGmod model | P25116 |
3D structure model | This structure is from PDB ID 3vw7. |
BioLiP | BL0217099 |
Therapeutic Target Database | T36483 |
ChEMBL | CHEMBL3974 |
IUPHAR | 347 |
DrugBank | BE0000928 |
Name | CHEMBL287156 |
---|---|
Molecular formula | C21H31N11O4 |
IUPAC name | 3-amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-1H-1,2,4-triazole-5-carboxamide |
Molecular weight | 501.552 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 8 |
XlogP | -1.5 |
Synonyms | BDBM50077773 5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-4-guanidino-butylcarbamoyl]-ethyl}-amide |
Inchi Key | BUCKWRREYIOIOM-UBHSHLNASA-N |
Inchi ID | InChI=1S/C21H31N11O4/c1-11(27-19(36)16-30-21(25)32-31-16)17(34)28-13(8-5-9-26-20(23)24)18(35)29-14(15(22)33)10-12-6-3-2-4-7-12/h2-4,6-7,11,13-14H,5,8-10H2,1H3,(H2,22,33)(H,27,36)(H,28,34)(H,29,35)(H4,23,24,26)(H3,25,30,31,32)/t11-,13-,14-/m0/s1 |
PubChem CID | 44280878 |
ChEMBL | CHEMBL287156 |
IUPHAR | N/A |
BindingDB | 50077773 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 46000.0 nM | PMID10360749 | BindingDB,ChEMBL |
Inhibition | >20.0 % | PMID10360749 | ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417