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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Delta-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRD1
Synonym	D-OR-1 DOR opioid receptor OP1 DOP DOPr DOR-1 Delta receptor [ Show all ]
Disease	Cough Overactive bladder disorder Bladder disease Moderate-to-severe pain Diarrhea-predominant IBS Major depressive disorder Urinary incontinence Rheumatoid arthritis Premature ejaculation Pain Acute migraine Ischemic heart diseases Acute nonspecific diarrhea; Chronic diarrhea associated with inflammatory bowel disease Alcohol use disorders Anxiety disorder [ Show all ]
Length	372
Amino acid sequence	MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
UniProt	P41143
Protein Data Bank	4rwd, 4rwa, 4n6h
GPCR-HGmod model	P41143
3D structure model	This structure is from PDB ID 4rwd.
BioLiP	BL0303696,BL0303697, BL0265712, BL0265705,BL0265706,BL0265707,, BL0303699,BL0303701, BL0303698,BL0303700
Therapeutic Target Database	T58992
ChEMBL	CHEMBL236
IUPHAR	317
DrugBank	BE0000420

Ligand

Name	Phencyclidine hydrochloride
Molecular formula	C17H26ClN
IUPAC name	1-(1-phenylcyclohexyl)piperidine;hydrochloride
Molecular weight	279.852
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	None
Synonyms	956-90-1 CHEMBL542581 DEA No. 7471 mcv4158 PCP hydrochloride Phencyclidine-d5 Hydrochloride Sernyl hydrochloride Trank 1-(1-Phenylcyclohexyl) piperidine hydrochloride. API0007830 CI395 FT-0602418 nih9580 Piperidine, 1-(1-phenylcyclohexyl)-, hydrochloride WLN: T6NTJ A- AL6TJ AR &GH 60124-79-0 C17H25N.HCl CN-25253-2 LS-115889 NSC40902 Phencyclidine hydrochloride, United States Pharmacopeia (USP) Reference Standard SCHEMBL21777 AB0095424 CI 395 Elysion MLS002320664 pcphydrochloride PHENCYLIDINE HYDROCHLORIDE Sernylan UNII-V1JZQ7GDTX 1-(1-phenylcyclohexyl)-piperidinhydrochloride AX8147413 Cl 395 hydrochloride GP 121 NSC 40902 Phencyclidine hydrochloride (USAN) QC-3096 6523AC D05453 MCV 4158 P-125 Phencyclidine Monohydrochloride Sernyl SMR001338811 AKOS015844481 CI-395 FT-0080143 NIH 9580 Phencyclidine HCl Phenylcyclidine hydrochloride V1JZQ7GDTX 1-(1-Phenylcyclohexyl)piperidine hydrochloride C.I. 395 CN-25,253-2 GP-121 NSC-40902 Phencyclidine hydrochloride [USAN] RW3111 [ Show all ]
Inchi Key	BUAJNGPDPGKBGV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25N.ClH/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18;/h1,4-5,10-11H,2-3,6-9,12-15H2;1H
PubChem CID	9795678
ChEMBL	CHEMBL542581
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	33637.0 nM	PubChem BioAssay data set	ChEMBL

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