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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Vasopressin V1a receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr1a
Synonym	AVPR AVPR V1a AVPR1 antidiuretic hormone receptor 1a V1A receptor V1aR Vascular/hepatic-type arginine vasopressin receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	424
Amino acid sequence	MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST
UniProt	P30560
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2868
IUPHAR	366
DrugBank	N/A

Ligand

Name	CHEMBL117566
Molecular formula	C25H24N2O2
IUPAC name	N-[4-(3,4-dihydro-2H-quinoline-1-carbonyl)phenyl]-2,4-dimethylbenzamide
Molecular weight	384.479
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.9
Synonyms	BDBM50052891 N-[4-(3,4-Dihydro-2H-quinoline-1-carbonyl)-phenyl]-2,4-dimethyl-benzamide
Inchi Key	BTQSMXQASOGCKJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H24N2O2/c1-17-9-14-22(18(2)16-17)24(28)26-21-12-10-20(11-13-21)25(29)27-15-5-7-19-6-3-4-8-23(19)27/h3-4,6,8-14,16H,5,7,15H2,1-2H3,(H,26,28)
PubChem CID	10667727
ChEMBL	CHEMBL117566
IUPHAR	N/A
BindingDB	50052891
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3300.0 nM	PMID8784453	BindingDB,ChEMBL

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