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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	CHEMBL51480
Molecular formula	C26H34FN3O2
IUPAC name	2-[[4-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-N-(3-methoxyphenyl)piperidine-1-carboxamide
Molecular weight	439.575
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.8
Synonyms	2-[4-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid (3-methoxy-phenyl)-amide BDBM50115018
Inchi Key	BSZULKCGCBLLIO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H34FN3O2/c1-32-25-7-4-5-23(18-25)28-26(31)30-14-3-2-6-24(30)19-29-15-12-21(13-16-29)17-20-8-10-22(27)11-9-20/h4-5,7-11,18,21,24H,2-3,6,12-17,19H2,1H3,(H,28,31)
PubChem CID	44295480
ChEMBL	CHEMBL51480
IUPHAR	N/A
BindingDB	50115018
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	170.0 nM	PMID12067561	BindingDB,ChEMBL

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