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GPCR

NameGlucagon-like peptide 2 receptor
SpeciesHomo sapiens (Human)
GeneGLP2R
SynonymGLP-2R
GLP-2-R
GLP-2 receptor
DiseaseDiarrhea
Gastrointestinal disease
Short bowel syndrome
Osteoporosis
Inflammatory bowel disease
Length553
Amino acid sequenceMKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMANTMEEILEESEI
UniProtO95838
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT34843
ChEMBLCHEMBL5844
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2178011
Molecular formulaC12H9Cl2NOS2
IUPAC name(NZ)-N-[1-(2,5-dichlorothiophen-3-yl)-2-phenylsulfanylethylidene]hydroxylamine
Molecular weight318.23
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP5.7
SynonymsN/A
Inchi KeySROFSCGLJHBGGF-XNTDXEJSSA-N
Inchi IDInChI=1S/C12H9Cl2NOS2/c13-11-6-9(12(14)18-11)10(15-16)7-17-8-4-2-1-3-5-8/h1-6,16H,7H2/b15-10+
PubChem CID71453655
ChEMBLCHEMBL2178011
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
%max55.0 %PMID22944117ChEMBL
%max110.0 %PMID22944117ChEMBL
%max150.0 %PMID22944117ChEMBL
%max490.0 %PMID22944117ChEMBL
%max701.0 %PMID22944117ChEMBL
%max930.0 %PMID22944117ChEMBL
Activity10.0 %PMID22944117ChEMBL
FC1.2 -PMID22944117ChEMBL
FC3.3 -PMID22944117ChEMBL
FC3.4 -PMID22944117ChEMBL
FC17.0 -PMID22944117ChEMBL

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