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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	Hyoscine methonitrate
Molecular formula	C18H24N2O7
IUPAC name	[(1R,2R,4S,5S)-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate;nitrate
Molecular weight	380.397
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	None
Synonyms	BDBM37635 HSDB 6104 METHYLSCOPOLAMINE NITRATE N-Methylscopolaminium-nitrat Scopolamine, compd with methyl nitrate (1:1) 3-Oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane, 7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-, nitrate (salt) C-56020 K0813KQM3V Methylscopolaminium nitricum Pylorpine Skopyl (-)-N-Methylhyoscinium nitrate 6106-46-3 EINECS 228-065-2 Methscopolamine nitrate MLS000028382 SCOPOLAMINE METHYL NITRATE Viscope 16868-00-1 3-Oxa-9-azoniatricyclo(3.3.1.02,4)nonane, 7-((2S)-3-hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-, (1alpha,2beta,4beta,5alpha,7beta)-, nitrate (1:1) Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-aztricyclo(3.3.1.0(2,4))non-7-yl ester, (7(S)-(1-alpha,2-beta,4-beta,5-alpha,7-beta))-, compd. with methyl nitrate (1:1) Methylscopolamini nitras N-Methylscopolammonium nitrate (6CI,7CI) Scotrate 51-33-2 CHEMBL1506225 Mescomine Methylscopolaminnitrat REGID_for_CID_657297 SMR000058604 1-alpha-H,5-alpha-H-Tropanium, 6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-, nitrate, (-)-tropate 7085-72-5 Epoxytropine tropate methylnitrate Methyl nitrate, compd with scopolamine N-Methylscopolamine nitrate Scopolamine methylnitrate 1alphaH,5alphaH-Tropanium, 6beta,7beta-epoxy-3alpha-hydroxy-8-methyl-, nitrate, (-)-tropate 3-Oxa-9-azoniatricyclo(3.3.1.02,4)nonane, 7-((2S)-3-hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-, (1alpha,2beta,4beta,5alpha,7beta)-, nitrate (salt) BSQIVYOSLFLSGE-OZVSTBQFSA-N Hyoscine methyl nitrate Methylscopolaminium nitrat Opera_ID_538 Skopolate 51541-33-4 cid_657297 Methnite MFCD00078239 Scopolamin-N-methylnitrat UNII-K0813KQM3V 13265-10-6 (Parent) [ Show all ]
Inchi Key	BSQIVYOSLFLSGE-OZVSTBQFSA-N
Inchi ID	InChI=1S/C18H24NO4.NO3/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11;2-1(3)4/h3-7,12-17,20H,8-10H2,1-2H3;/q+1;-1/t12?,13-,14-,15+,16-,17+;/m1./s1
PubChem CID	657297
ChEMBL	N/A
IUPHAR	N/A
BindingDB	37635
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<43700.0 nM	N/A	BindingDB

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