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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M3
Species	Rattus norvegicus (Rat)
Gene	Chrm3
Synonym	M3R M3 receptor HM4 Chrm-3 cholinergic receptor, muscarinic 3, cardiac cholinergic receptor, muscarinic 3 cholinergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	589
Amino acid sequence	MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
UniProt	P08483
Protein Data Bank	4daj, 4u14, 4u15, 4u16, 5zhp
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4daj.
BioLiP	BL0433837, BL0433838,BL0433839, BL0300355,BL0300356, BL0300353,BL0300354, BL0223908,BL0223909,BL0223910,, BL0300352
Therapeutic Target Database	N/A
ChEMBL	CHEMBL320
IUPHAR	15
DrugBank	N/A

Ligand

Name	BAS 07465564
Molecular formula	C20H24ClN3O2
IUPAC name	N-[3-chloro-4-(4-ethylpiperazin-1-yl)phenyl]-2-phenoxyacetamide
Molecular weight	373.881
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.7
Synonyms	MolPort-002-010-963 N-[3-chloro-4-(4-ethylpiperazinyl)phenyl]-2-phenoxyacetamide CHEMBL429780 ZINC809781 AC1LLTP3 N-[3-Chloro-4-(4-ethyl-piperazin-1-yl)-phenyl]-2-phenoxy-acetamide BDBM50373832 ST50027334 MCULE-8370106855 AKOS000431458 N-[3-chloro-4-(4-ethylpiperazin-1-yl)phenyl]-2-phenoxyacetamide STK135801 [ Show all ]
Inchi Key	SNYLXINFZFDVHF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H24ClN3O2/c1-2-23-10-12-24(13-11-23)19-9-8-16(14-18(19)21)22-20(25)15-26-17-6-4-3-5-7-17/h3-9,14H,2,10-13,15H2,1H3,(H,22,25)
PubChem CID	1090206
ChEMBL	CHEMBL429780
IUPHAR	N/A
BindingDB	50373832
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<150000.0 nM	PMID18178088	BindingDB,ChEMBL

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