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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Rattus norvegicus (Rat)
Gene	Chrm5
Synonym	cholinergic receptor cholinergic receptor, muscarinic 5 M5 receptor M5R
Disease	N/A for non-human GPCRs
Length	531
Amino acid sequence	MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08911
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL277
IUPHAR	17
DrugBank	N/A

Ligand

Name	BAS 07465564
Molecular formula	C20H24ClN3O2
IUPAC name	N-[3-chloro-4-(4-ethylpiperazin-1-yl)phenyl]-2-phenoxyacetamide
Molecular weight	373.881
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.7
Synonyms	STK135801 MolPort-002-010-963 N-[3-chloro-4-(4-ethylpiperazinyl)phenyl]-2-phenoxyacetamide CHEMBL429780 ZINC809781 N-[3-Chloro-4-(4-ethyl-piperazin-1-yl)-phenyl]-2-phenoxy-acetamide AC1LLTP3 ST50027334 BDBM50373832 MCULE-8370106855 N-[3-chloro-4-(4-ethylpiperazin-1-yl)phenyl]-2-phenoxyacetamide AKOS000431458 [ Show all ]
Inchi Key	SNYLXINFZFDVHF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H24ClN3O2/c1-2-23-10-12-24(13-11-23)19-9-8-16(14-18(19)21)22-20(25)15-26-17-6-4-3-5-7-17/h3-9,14H,2,10-13,15H2,1H3,(H,22,25)
PubChem CID	1090206
ChEMBL	CHEMBL429780
IUPHAR	N/A
BindingDB	50373832
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<150000.0 nM	PMID18178088	BindingDB,ChEMBL

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