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GPCR

NameD(1A) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd1
SynonymD1 receptor
D1A
DADR
dopamine D1 receptor
Dopamine-1A receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProtP18901
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL265
IUPHAR214
DrugBankN/A

Ligand

NameCHEMBL2112388
Molecular formulaC10H12N2O2
IUPAC name(3R)-3-amino-3,4-dihydro-2H-chromene-5-carboxamide
Molecular weight192.218
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP-0.1
Synonyms294843-55-3
2H-1-Benzopyran-5-carboxamide, 3-amino-3,4-dihydro-, (3R)-
(R)-3-Amino-3,4-dihydro-2H-1-benzopyran-5-carboxamide
Inchi KeyBSIXOZMGFYGXST-ZCFIWIBFSA-N
Inchi IDInChI=1S/C10H12N2O2/c11-6-4-8-7(10(12)13)2-1-3-9(8)14-5-6/h1-3,6H,4-5,11H2,(H2,12,13)/t6-/m1/s1
PubChem CID10679285
ChEMBLCHEMBL2112388
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID10956192ChEMBL

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