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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	CHEMBL2112388
Molecular formula	C10H12N2O2
IUPAC name	(3R)-3-amino-3,4-dihydro-2H-chromene-5-carboxamide
Molecular weight	192.218
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-0.1
Synonyms	2H-1-Benzopyran-5-carboxamide, 3-amino-3,4-dihydro-, (3R)- (R)-3-Amino-3,4-dihydro-2H-1-benzopyran-5-carboxamide 294843-55-3
Inchi Key	BSIXOZMGFYGXST-ZCFIWIBFSA-N
Inchi ID	InChI=1S/C10H12N2O2/c11-6-4-8-7(10(12)13)2-1-3-9(8)14-5-6/h1-3,6H,4-5,11H2,(H2,12,13)/t6-/m1/s1
PubChem CID	10679285
ChEMBL	CHEMBL2112388
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2930.0 nM	PMID10956192	ChEMBL

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