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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(1A) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd1
Synonym	D1 receptor D1A DADR Dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	Q61616
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3071
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Tilozepine
Molecular formula	C17H18ClN3S
IUPAC name	7-chloro-4-(4-methylpiperazin-1-yl)-10H-thieno[3,2-c][1]benzazepine
Molecular weight	331.862
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.2
Synonyms	NSC_172286 7-chloro-4-(4-methylpiperazin-1-yl)-10H-thieno[3,2-c][1]benzazepine BDBM81985 Tilozepina 10H-Thieno(3,2-c)(1)benzazepine, 7-chloro-4-(4-methyl-1-piperazinyl)- DTXSID30195074 UNII-3RG8Q831DX 7-chloro-10-(4-methyl-piperazin-1-yl)-4H-3-thia-9-aza-benzo(f)azulene NT 104-252 CAS_42239-60-1 3RG8Q831DX L001129 ZINC31490523 7-chloro-4-(4-methyl-1-piperazinyl)-10H-Thieno(3,2-c)(1)benzazepine AC1L58W0 SCHEMBL2110610 CHEMBL2105484 Tilozepine [INN] 42239-60-1 [ Show all ]
Inchi Key	SKASXEDXLXEXKN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H18ClN3S/c1-20-5-7-21(8-6-20)17-14-4-9-22-16(14)10-12-2-3-13(18)11-15(12)19-17/h2-4,9,11H,5-8,10H2,1H3
PubChem CID	172286
ChEMBL	N/A
IUPHAR	N/A
BindingDB	81985
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	17.0 nM	PMID2895008	BindingDB

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