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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 3
Species	Homo sapiens (Human)
Gene	GRM3
Synonym	GPRC1C mGluR3 mGlu3 receptor glutamate receptor
Disease	Alzheimer disease; Major depressive disorder Anxiety disorder Schizophrenia
Length	879
Amino acid sequence	MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProt	Q14832
Protein Data Bank	3sm9, 6b7h, 4xar, 5cnk, 5cnm
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 3sm9.
BioLiP	BL0324562, BL0307715, BL0204618, BL0324563, BL0412294, BL0412295, BL0324561
Therapeutic Target Database	T02719
ChEMBL	CHEMBL2888
IUPHAR	291
DrugBank	N/A

Ligand

Name	SIB 1893
Molecular formula	C14H13N
IUPAC name	2-methyl-6-[(E)-2-phenylethenyl]pyridine
Molecular weight	195.265
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	3.6
Synonyms	AC1Q4VO3 CHEBI:93178 L000561 NCGC00025046-04 PDSP2_001555 SR-01000076143 2-methyl-6-(2-phenylethenyl)pyridine 2-[(E)-Styryl]-6-methylpyridine BDBM50084141 EU-0101171 MFCD02262120 NCGC00261856-01 Tox21_501171 (E)-2-Methyl-6-(2-phenylethyl)-pyridine 7370-21-0 CAS_5311432 KB-231610 NCGC00025046-02 NSC_5311432 SIB1893 2-Methyl-6-styryl-pyridine(SIB-1893) AKOS006279967 Lopac0_001171 NCGC00025046-05 Pyridine,2-methyl-6-(2-phenylethenyl)- SR-01000076143-1 BDBM86715 GTPL1432 MLS002607995 NSC-36665 SIB 1893, >99%, solid ZINC3941522 (E)-2-methyl-6-styrylpyridine AC1NSKMI CCG-205245 KB-60434 NCGC00025046-03 PDSP1_001571 SMR000326914 2-Methyl-6-((E)-styryl)-pyridine 2-methyl-6-[(E)-2-phenylethenyl]pyridine BC600133 CHEMBL88612 LP01171 NCGC00025046-06 S 9311 SR-01000076143-3 6266-99-5 BRD-K67439147-001-01-7 HMS3263L03 MolPort-003-959-634 NSC36665 SIB-1893 [E]-2-Methyl-6-[2-phenylethenyl]pyridine (E)-2-Methyl-6-[2-phenylethenyl]pyridine [ Show all ]
Inchi Key	SISOFUCTXZKSOQ-ZHACJKMWSA-N
Inchi ID	InChI=1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
PubChem CID	5311432
ChEMBL	CHEMBL88612
IUPHAR	1432
BindingDB	50084141
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<100000.0 nM	PMID10893301	BindingDB,ChEMBL

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