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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1989216
Molecular formulaC22H21ClN2O5
IUPAC namediethyl 2-[5-chloro-2-(naphthalen-1-ylmethyl)-3-oxopyridazin-4-yl]propanedioate
Molecular weight428.869
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP3.7
SynonymsSR-02000001292
SR-02000001292-1
Inchi KeyBRVRNNCTGPTWPK-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H21ClN2O5/c1-3-29-21(27)19(22(28)30-4-2)18-17(23)12-24-25(20(18)26)13-15-10-7-9-14-8-5-6-11-16(14)15/h5-12,19H,3-4,13H2,1-2H3
PubChem CID53245498
ChEMBLCHEMBL1989216
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC503770.0 nMPubChem BioAssay data setChEMBL

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