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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptides B/W receptor type 1
Species	Homo sapiens (Human)
Gene	NPBWR1
Synonym	G protein-coupled receptor 7 G-protein coupled receptor 7 GPR7 neuropeptides B/W receptor type 1 NPBW1 receptor
Disease	N/A
Length	328
Amino acid sequence	MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProt	P48145
Protein Data Bank	N/A
GPCR-HGmod model	P48145
3D structure model	This predicted structure model is from GPCR-EXP P48145.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293293
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SR-02000000355
Molecular formula	C20H19ClN2O3
IUPAC name	5-chloro-4-[4-(hydroxymethyl)phenoxy]-2-(4-propan-2-ylphenyl)pyridazin-3-one
Molecular weight	370.833
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.8
Synonyms	5-chloro-4-[4-(hydroxymethyl)phenoxy]-2-(4-propan-2-ylphenyl)-3-pyridazinone SR-02000000355-1 BDBM75887 5-chloranyl-4-[4-(hydroxymethyl)phenoxy]-2-(4-propan-2-ylphenyl)pyridazin-3-one cid_46172918 5-chloro-4-[4-(hydroxymethyl)phenoxy]-2-(4-propan-2-ylphenyl)pyridazin-3-one SR-02000000355-2 5-chloro-4-(4-methylolphenoxy)-2-p-cumenyl-pyridazin-3-one SR-02000000355-3 CHEMBL1710128 [ Show all ]
Inchi Key	BRSNXYWTPOJCCY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H19ClN2O3/c1-13(2)15-5-7-16(8-6-15)23-20(25)19(18(21)11-22-23)26-17-9-3-14(12-24)4-10-17/h3-11,13,24H,12H2,1-2H3
PubChem CID	46172918
ChEMBL	CHEMBL1710128
IUPHAR	N/A
BindingDB	75887
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	650.0 nM	, PubChem BioAssay data set, PMID23079522	BindingDB,ChEMBL

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