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GPCR

Name	Alpha-1B adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1B
Synonym	alpha1B-adrenoceptor alpha1B-adrenergic receptor Alpha-1B adrenoreceptor Alpha-1B adrenoceptor alpha 1B-adrenoreceptor alpha 1B-adrenoceptor adrenergic receptor adrenergic alpha 1B receptor [ Show all ]
Disease	Psychiatric disorder Hypertension Exogenous obesity Attention deficit hyperactivity disorder
Length	520
Amino acid sequence	MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
UniProt	P35368
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T29500
ChEMBL	CHEMBL232
IUPHAR	23
DrugBank	BE0000575

Ligand

Name	dl-Arterenol
Molecular formula	C8H11NO3
IUPAC name	4-(2-amino-1-hydroxyethyl)benzene-1,2-diol
Molecular weight	169.18
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-1.2
Synonyms	(.+/-.)-Noradrenaline 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (+-)- (9CI) AC1L1AE8 BENZYL ALCOHOL, alpha-(AMINOMETHYL)-3,4-DIHYDROXY-, (+-)- d-Norepinephrine EINECS 205-337-9 NCGC00185992-01 NSC 294898 ST50410590 [3H]NE 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (RS)- 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol # AKOS022180874 CHEBI:33569 DL-Arterenol, dl-Norepinephrine, EINECS 205-337-9, (+/-)-Noradrenaline L000933 Noradrenaline,(+) PDSP1_001514 (+-)-Noradrenaline 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)- 138-65-8 Benzyl alcohol, .alpha.-(aminomethyl)-3,4-dihydroxy-, (.+/-.)- CTK5A3318 DL-[7-3H]norepinephrine MCULE-6262207923 Norepinephrine, (+,-)-Isomer SFLSHLFXELFNJZ-UHFFFAOYSA-N (.+-.)-Norepinephrine (.+/-.)-Norepinephrine 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (.+/-.)- 4-(1-Hydroxy-2-aminoethyl)catechol AC1Q7AC5 Benzyl alcohol,4-dihydroxy-, (.+-.)- D06GJW EINECS 205-750-4 Noradrenalin, dl- NSC-294898 WLN: Z1YQR CQ DQ 1, 4-(2-amino-1-hydroxyethyl)- 1,2-Benzenediol,4-(2-amino-1-hydroxyethyl)-, hydrochloride (1:1) 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol BCP04227 dl-Noradrenaline LS-42677 Noradrop PDSP2_001498 (+/-)Arterenol (.+/-.)-Arterenol 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (+-)- 2-amino-1-(3,4-dihydroxyphenyl)ethanol AC-10030 BENZYL ALCOHOL, alpha-(AMINOMETHYL)-3,4-DIHYDROXY-, (+)- d-Arterenol EBD3051430 MFCD00025592 Norepinephrine, DL- SR-01000075279-3 (1)-4-(2-Amino-1-hydroxyethyl)pyrocatechol 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (dl)- 4-(2-amino-1-hydroxy-ethyl)benzene-1,2-diol AKOS000123495 CCG-204148 GTPL484 Noradrenaline, racemic mixture NSC294898 ( inverted exclamation markA)-\|A-(Aminomethyl)-3,4-dihydroxybenzyl alcohol xi-Norepinephrine 1, 4-(2-amino-1-hydroxyethyl)-, (.+-.)- 1-(3,4-Dihydroxy)phenyl-2-aminoethanol 4-[(1rs)-2-amino-1-hydroxyethyl]-1,2-benzenediol BDBM35234 CHEMBL432 dl-Norepinephrine LS-42678 Norepinephrine, (+)-Isomer SCHEMBL2610 (.+-.)-Noradrenaline [ Show all ]
Inchi Key	SFLSHLFXELFNJZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2
PubChem CID	951
ChEMBL	CHEMBL432
IUPHAR	484
BindingDB	35234
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID19857969	PDSP
Ki	7585.78 nM	PMID12065700	PDSP
Ki	7585.78 nM	PMID12065700	BindingDB

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