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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	norepinephrine
Molecular formula	C8H11NO3
IUPAC name	4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Molecular weight	169.18
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-1.2
Synonyms	Levoarterenol (R)-4-(2-Amino-1-hydroxyethyl)catechol CCG-40104 MLS006010883 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(-)- d-Norepinephrine NCGC00159406-10 21779-EP2287165A2 DivK1c_000230 Noradrenalin 21779-EP2314571A2 FT-0603221 Norartrinal 4786-EP2284171A1 HSDB 7772 Norepinephrine Noradrenalin 4786-EP2305677A1 KBio3_001579 PDSP1_001111 4899-05-2 L-Noradrenaline SFLSHLFXELFNJZ-QMMMGPOBSA-N AB00052424_08 Spectrum5_001068 ALBB-006229 (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2 UNII-X4W3ENH1CV bmse000404 xi-Norepinephrine C-05156 Levonorepinephrine 025N592 CHEMBL1437 NCGC00159406-05 1,2-Benzenediol,4-(2-amino-1-hydroxyethyl)- D0R2UN NINDS_000230 21779-EP2298731A1 DSSTox_RID_77004 Noradrenalina [Italian] 4-[(1R)-2-amino-1-hydroxy-ethyl]benzene-1,2-diol GTPL505 norepinefrina 4786-EP2287166A2 IDI1_000230 norepinephrinum 4786-EP2308873A1 l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol PubChem6074 51-40-1 (l-tartrate (1:1)) Levarterenolo SPBio_001048 Adrenor (-)-(R)-Norepinephrine Sympathin E API0003193 (-)-Norepinephrine, >=98%, crystalline (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol CAS-51-41-2 LT03330026 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- D-(-)-Noradrenaline NCGC00159406-08 21779-EP2272847A1 DB00368 Nor-adrenaline 21779-EP2311828A1 EINECS 200-096-6 Noradrenaline (JP17) 4786-EP2270011A1 HMS2091J08 Norepinephrine (INN) 4786-EP2305644A1 KBio2_004057 NSC-757246 4786-EP2314571A2 L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol SC-04955 AB00052424-06 Spectrum3_000520 AKOS015854572 (-)-Arterenol free base TR-005105 Benzyl alcohol, .alpha.-(aminomethyl)-3,4-dihydroxy-, (+)- Levonor (R)-Noradrenaline CHEBI:18357 NCGC00159406-03 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(9CI) D00076 NCGC00159406-11 21779-EP2287166A2 DSSTox_CID_3378 Noradrenalin, l- 21779-EP2377510A1 FT-0658803 Noreinefrina 4786-EP2287163A1 HY-13715 Norepinephrine [INN:BAN:JAN] 4786-EP2305678A1 KBioGR_000635 PDSP2_001095 L-Norepinephrine SGCUT00123 AC1L96ZT (+)-Noradrenaline Spectrum_001009 AN-24392 (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2-?amino-?1-?hydroxyethyl]?- W-105896 BRN 4231961 ZINC57624 C-4015 Levophed 1,2-Benzenediol, 4-((1R)-2-amino-1-hydroxyethyl)- CS-0007744 NCGC00159406-06 138-65-8 D53D5E3A-2360-4CA9-8031-6C2CD4062FD5 Nor adrenalin 21779-EP2298742A1 DTXSID5023378 noradrenaline 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol HMS1920B08 NOREPINEPHIRINE 4786-EP2292620A2 KBio1_000230 Norepinephrinum [INN-Latin] 4786-EP2308875A1 l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol R-norepinephrine 51-41-2 SPECTRUM1500436 AJ-09755 (-)-alpha-(Aminomethyl)protocatechuyl alcohol Tox21_301944 Arterenol (R)-( C)-Norepinephrine Levarterenolo [DCIT] (R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol CC-33071 MFCD00025592 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- (9CI) d-Arterenol NCGC00159406-09 21779-EP2284170A1 DermX Nor-Epirenan 21779-EP2311835A1 FCH920095 Noradrenalinum 4786-EP2280010A2 HMS500L12 Norepinephrine l-Tartrate (1:1) 4786-EP2305648A1 KBio2_006625 NSC757246 4786-EP2316836A1 L-arterenol SCHEMBL2609 AB00052424_07 Spectrum4_000078 Aktamin (-)-NORADRENALINE UNII-K294OAI79V component SFLSHLFXELFNJZ-QMMMGPOBSA-N Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, (-)- BSPBio_002079 Levonoradrenaline (R)-Norepinephrine NCGC00159406-04 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]- D07MOX NCGC00255328-01 21779-EP2292620A2 DSSTox_GSID_23378 Noradrenalina 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol FT-0679201 Noreinefrina [INN-Spanish] 4786-EP2287165A2 I01-15661 Norepinephrine [INN:JAN] 4786-EP2308864A1 KBioSS_001489 Pharmakon1600-01500436 Levarterenol SMR000058585 Adrenaline Impurity (+)-Norepinephrine STK503776 ANW-74377 (-)-Norepinephrine X4W3ENH1CV C00547 LS-42676 1,2-Benzenediol, 4-((R)-2-amino-1-hydroxyethyl)- CTK4C1344 NCGC00159406-07 21779-EP2269990A1 Nor adrenalin (TN) 21779-EP2305669A1 Ecteinascidins Noradrenaline (JP15) 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol HMS2089E18 4786-EP2298776A1 KBio2_001489 Norepirenamine 4786-EP2311831A1 L-3,4-dihydroxyphenylethanolamine SBI-0050082.P003 66197-73-7 Spectrum2_001064 AKOS006345192 (-)-Arterenol to_000024 BDBM50029051 (R)-(-)-Norepinephrine [ Show all ]
Inchi Key	SFLSHLFXELFNJZ-QMMMGPOBSA-N
Inchi ID	InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
PubChem CID	439260
ChEMBL	CHEMBL1437
IUPHAR	505
BindingDB	50029051
DrugBank	DB00368
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
EC50	794.0 nM	PMID18578476, PMID17630725, PMID19886609	BindingDB
EC50	794.33 nM	PMID15566287, PMID17630725, PMID18578476, PMID19886609	ChEMBL
Intrinsic activity	1.0 -	PMID15566287, PMID19886609	ChEMBL
Ki	63.0 nM	PMID8632424	BindingDB,ChEMBL
Ki	158.489 - 1995.26 nM	PMID9824686, PMID9605427	IUPHAR

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