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GPCR

Name	Alpha-1D adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1d
Synonym	ADRA1A Gpcr8 Adra-1 alpha1D-AR alpha1D-adrenoceptor alpha1a/d-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-1D adrenoreceptor Alpha-1D adrenoceptor ADRA1 Alpha-1A adrenergic receptor alpha 1D-adrenoreceptor alpha 1D-adrenoceptor adrenergic receptor delta1 Adrd1 ADRA1R RA42 [ Show all ]
Disease	N/A for non-human GPCRs
Length	561
Amino acid sequence	MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
UniProt	P23944
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL326
IUPHAR	24
DrugBank	N/A

Ligand

Name	norepinephrine
Molecular formula	C8H11NO3
IUPAC name	4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Molecular weight	169.18
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-1.2
Synonyms	Spectrum5_001068 (-)-(R)-Norepinephrine API0003193 UNII-X4W3ENH1CV (-)-Norepinephrine, >=98%, crystalline Levoarterenol C-05156 025N592 MLS006010883 CHEMBL1437 1,2-Benzenediol,4-(2-amino-1-hydroxyethyl)- NCGC00159406-10 D0R2UN 21779-EP2298731A1 Noradrenalin DSSTox_RID_77004 4-[(1R)-2-amino-1-hydroxy-ethyl]benzene-1,2-diol Norartrinal GTPL505 4786-EP2287166A2 Norepinephrine Noradrenalin IDI1_000230 4786-EP2308873A1 PDSP1_001111 l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol 51-40-1 (l-tartrate (1:1)) SFLSHLFXELFNJZ-QMMMGPOBSA-N Levarterenolo Adrenor AKOS015854572 Sympathin E (-)-Arterenol free base Benzyl alcohol, .alpha.-(aminomethyl)-3,4-dihydroxy-, (+)- xi-Norepinephrine (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol Levonorepinephrine CAS-51-41-2 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- NCGC00159406-05 D-(-)-Noradrenaline 21779-EP2272847A1 NINDS_000230 DB00368 21779-EP2311828A1 Noradrenalina [Italian] EINECS 200-096-6 4786-EP2270011A1 norepinefrina HMS2091J08 4786-EP2305644A1 norepinephrinum KBio2_004057 4786-EP2314571A2 PubChem6074 L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol AB00052424-06 SPBio_001048 Spectrum3_000520 (+)-Noradrenaline AN-24392 TR-005105 (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2-?amino-?1-?hydroxyethyl]?- BRN 4231961 (R)-Noradrenaline LT03330026 CHEBI:18357 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(9CI) NCGC00159406-08 D00076 21779-EP2287166A2 Nor-adrenaline DSSTox_CID_3378 21779-EP2377510A1 Noradrenaline (JP17) FT-0658803 4786-EP2287163A1 Norepinephrine (INN) HY-13715 4786-EP2305678A1 NSC-757246 KBioGR_000635 SC-04955 L-Norepinephrine AC1L96ZT AJ-09755 Spectrum_001009 (-)-alpha-(Aminomethyl)protocatechuyl alcohol Arterenol W-105896 (R)-( C)-Norepinephrine Levonor C-4015 1,2-Benzenediol, 4-((1R)-2-amino-1-hydroxyethyl)- NCGC00159406-03 CS-0007744 138-65-8 NCGC00159406-11 D53D5E3A-2360-4CA9-8031-6C2CD4062FD5 21779-EP2298742A1 Noradrenalin, l- DTXSID5023378 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol Noreinefrina HMS1920B08 4786-EP2292620A2 Norepinephrine [INN:BAN:JAN] KBio1_000230 4786-EP2308875A1 PDSP2_001095 l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol 51-41-2 SGCUT00123 Aktamin Tox21_301944 (-)-NORADRENALINE Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, (-)- ZINC57624 (R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol Levophed CC-33071 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- (9CI) NCGC00159406-06 d-Arterenol 21779-EP2284170A1 Nor adrenalin DermX 21779-EP2311835A1 noradrenaline FCH920095 4786-EP2280010A2 NOREPINEPHIRINE HMS500L12 4786-EP2305648A1 Norepinephrinum [INN-Latin] KBio2_006625 4786-EP2316836A1 R-norepinephrine L-arterenol AB00052424_07 SPECTRUM1500436 Spectrum4_000078 (+)-Norepinephrine ANW-74377 UNII-K294OAI79V component SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-Norepinephrine Levarterenolo [DCIT] BSPBio_002079 (R)-Norepinephrine MFCD00025592 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]- NCGC00159406-09 D07MOX 21779-EP2292620A2 Nor-Epirenan DSSTox_GSID_23378 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol Noradrenalinum FT-0679201 4786-EP2287165A2 Norepinephrine l-Tartrate (1:1) I01-15661 4786-EP2308864A1 NSC757246 KBioSS_001489 SCHEMBL2609 Levarterenol Adrenaline Impurity AKOS006345192 STK503776 (-)-Arterenol BDBM50029051 X4W3ENH1CV (R)-(-)-Norepinephrine Levonoradrenaline C00547 1,2-Benzenediol, 4-((R)-2-amino-1-hydroxyethyl)- NCGC00159406-04 CTK4C1344 21779-EP2269990A1 NCGC00255328-01 21779-EP2305669A1 Noradrenalina Ecteinascidins 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol Noreinefrina [INN-Spanish] HMS2089E18 4786-EP2298776A1 Norepinephrine [INN:JAN] KBio2_001489 4786-EP2311831A1 Pharmakon1600-01500436 L-3,4-dihydroxyphenylethanolamine 66197-73-7 SMR000058585 Spectrum2_001064 ALBB-006229 to_000024 (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2 bmse000404 (R)-4-(2-Amino-1-hydroxyethyl)catechol LS-42676 CCG-40104 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(-)- NCGC00159406-07 d-Norepinephrine 21779-EP2287165A2 Nor adrenalin (TN) DivK1c_000230 21779-EP2314571A2 Noradrenaline (JP15) FT-0603221 4786-EP2284171A1 HSDB 7772 4786-EP2305677A1 Norepirenamine KBio3_001579 4899-05-2 SBI-0050082.P003 L-Noradrenaline AB00052424_08 [ Show all ]
Inchi Key	SFLSHLFXELFNJZ-QMMMGPOBSA-N
Inchi ID	InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
PubChem CID	439260
ChEMBL	CHEMBL1437
IUPHAR	505
BindingDB	50029051
DrugBank	DB00368
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	12.02 nM	PMID8831777	ChEMBL
Emax	113.0 %	PMID8831777	ChEMBL
Ki	22.39 nM	PMID8831777	ChEMBL
Ki	501.187 nM	PMID7969082	IUPHAR

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