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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Urotensin-2 receptor
Species	Homo sapiens (Human)
Gene	UTS2R
Synonym	urotensin II receptor UT receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) GPR14 G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	Asthma Diabetic nephropathy Renal failure
Length	389
Amino acid sequence	MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
UniProt	Q9UKP6
Protein Data Bank	N/A
GPCR-HGmod model	Q9UKP6
3D structure model	This predicted structure model is from GPCR-EXP Q9UKP6.
BioLiP	N/A
Therapeutic Target Database	T49072
ChEMBL	CHEMBL3764
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL2348511
Molecular formula	C21H24BrF3N2O3
IUPAC name	N-[(2-bromo-4,5-dimethoxyphenyl)methyl]-3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)aniline
Molecular weight	489.333
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	5.1
Synonyms	BDBM50431962
Inchi Key	SEYZORXZDBCUHS-HNNXBMFYSA-N
Inchi ID	InChI=1S/C21H24BrF3N2O3/c1-27-7-6-15(12-27)30-18-9-14(4-5-16(18)21(23,24)25)26-11-13-8-19(28-2)20(29-3)10-17(13)22/h4-5,8-10,15,26H,6-7,11-12H2,1-3H3/t15-/m0/s1
PubChem CID	71719581
ChEMBL	CHEMBL2348511
IUPHAR	N/A
BindingDB	50431962
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	191.0 nM	PMID23453841	BindingDB,ChEMBL
IC50	217.0 nM	PMID23453841	BindingDB,ChEMBL

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