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GPCR

NameHistamine H2 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh2
Synonymgastric receptor I
H2 receptor
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
UniProtP25102
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4654
IUPHAR263
DrugBankN/A

Ligand

NameCHEMBL1077862
Molecular formulaC10H16N6
IUPAC name1-cyano-3-[4-(1H-imidazol-5-yl)butyl]-2-methylguanidine
Molecular weight220.28
Hydrogen bond acceptor3
Hydrogen bond donor3
XlogP0.0
SynonymsGuanidine, N-cyano-N'-[4-(1H-imidazol-4-yl)butyl]-N''-methyl-
BDBM50415657
CTK1G2796
Guanidine, N-cyano-N'-[4-(1H-imidazol-5-yl)butyl]-N''-methyl-
DTXSID90475147
[ Show all ]
Inchi KeySESBNJZEWNWYQM-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H16N6/c1-12-10(15-7-11)14-5-3-2-4-9-6-13-8-16-9/h6,8H,2-5H2,1H3,(H,13,16)(H2,12,14,15)
PubChem CID11983344
ChEMBLCHEMBL1077862
IUPHARN/A
BindingDB50415657
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Kb7100.0 nMPMID17751ChEMBL

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