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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS001207850
Molecular formula	C14H12ClN3O
IUPAC name	4-chloro-N-[(E)-1-pyridin-2-ylethylideneamino]benzamide
Molecular weight	273.72
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.9
Synonyms	4-Chloro-benzoic acid (1-pyridin-2-yl-ethylidene)-hydrazide BAS 00296243 MolPort-019-783-399 SR-01000357044 4-chloro-N-(1-pyridin-2-ylethylideneamino)benzamide STK446818 4-Chlorobenzoic acid(1-pyridin-2-ylethylidene)-hydrazide 4-chloro-N'-[(1E)-1-(pyridin-2-yl)ethylidene]benzohydrazide BDBM60275 N-((1E)-2-(2-pyridyl)-1-azaprop-1-enyl)(4-chlorophenyl)carboxamide SR-01000357044-1 4-chloro-N-[1-(2-pyridinyl)ethylideneamino]benzamide CHEMBL3192432 4-chloranyl-N-(1-pyridin-2-ylethylideneamino)benzamide AKOS000514617 MolPort-001-032-805 4-Chloro-N'-[(E)-1-(2-pyridinyl)ethylidene]benzohydrazide # BRPAABKVWTVIPX-LICLKQGHSA-N SMR000513349 ST50299365 4-chloro-N-[1-(2-pyridyl)ethylideneamino]benzamide cid_571783 [ Show all ]
Inchi Key	BRPAABKVWTVIPX-LICLKQGHSA-N
Inchi ID	InChI=1S/C14H12ClN3O/c1-10(13-4-2-3-9-16-13)17-18-14(19)11-5-7-12(15)8-6-11/h2-9H,1H3,(H,18,19)/b17-10+
PubChem CID	9590741
ChEMBL	CHEMBL3192432
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	5623.4 nM	PubChem BioAssay data set	ChEMBL

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