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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger1
Synonym	EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa prostanoid EP1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
UniProt	P70597
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5068
IUPHAR	340
DrugBank	N/A

Ligand

Name	SCHEMBL6117314
Molecular formula	C21H16FN3O3
IUPAC name	6-[(6-fluoro-5-methoxy-2-pyridin-3-ylindol-1-yl)methyl]pyridine-2-carboxylic acid
Molecular weight	377.375
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.1
Synonyms	US8680120, 25-33 CHEMBL3665569 BDBM119475
Inchi Key	RZPLBSGRSHMBGQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H16FN3O3/c1-28-20-9-14-8-18(13-4-3-7-23-11-13)25(19(14)10-16(20)22)12-15-5-2-6-17(24-15)21(26)27/h2-11H,12H2,1H3,(H,26,27)
PubChem CID	69670812
ChEMBL	CHEMBL3665569
IUPHAR	N/A
BindingDB	119475
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	58.0 nM	, None	BindingDB,ChEMBL

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