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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	1-(4-chlorophenyl)-3-(2-hydroxy-5-methylphenyl)propane-1,3-dione
Molecular formula	C16H13ClO3
IUPAC name	1-(4-chlorophenyl)-3-(2-hydroxy-5-methylphenyl)propane-1,3-dione
Molecular weight	288.727
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.3
Synonyms	3-(4-chlorophenyl)-1-(2-hydroxy-5-methylphenyl)propane-1,3-dione DTXSID60382859 SCHEMBL12532247 AC1MD7W3 MCULE-6703669723 SR-01000394878-1 1-(2-Hydroxy-5-methylphenyl)-3-(4-chlorophenyl)-1,3-propanedione CHEMBL1463470 Oprea1_439080 ZINC1506038 3-(4-chlorophenyl)-3-hydroxy-1-(2-hydroxy-5-methyl-phenyl)prop-2-en-1-one HMS2875B12 SMR000554557 AKOS001578266 MLS001195014 ST51065369 CTK5B1448 REGID_for_CID_2785126 60402-29-1 KB-214589 SR-01000394878 MolPort-000-875-427 STK925879 [ Show all ]
Inchi Key	AALQRZYXRYPZSN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClO3/c1-10-2-7-14(18)13(8-10)16(20)9-15(19)11-3-5-12(17)6-4-11/h2-8,18H,9H2,1H3
PubChem CID	2785126
ChEMBL	CHEMBL1463470
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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