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GPCR

NameUrotensin-2 receptor
SpeciesHomo sapiens (Human)
GeneUTS2R
Synonymurotensin II receptor
UT receptor
UR-II-R
UR-2-R
UII-R1
[ Show all ]
DiseaseAsthma
Diabetic nephropathy
Renal failure
Length389
Amino acid sequenceMALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
UniProtQ9UKP6
Protein Data BankN/A
GPCR-HGmod modelQ9UKP6
3D structure modelThis predicted structure model is from GPCR-EXP Q9UKP6.
BioLiPN/A
Therapeutic Target DatabaseT49072
ChEMBLCHEMBL3764
IUPHAR365
DrugBankN/A

Ligand

NameCHEMBL437216
Molecular formulaC29H35N3O
IUPAC name2-[methyl(naphthalen-2-yl)amino]-1-[(2R,3R)-3-phenyl-2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethanone
Molecular weight441.619
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP5.7
SynonymsN/A
Inchi KeyADUBKELDHZMPAG-IZLXSDGUSA-N
Inchi IDInChI=1S/C29H35N3O/c1-30(26-16-15-23-10-5-6-13-25(23)20-26)22-29(33)32-19-9-14-27(24-11-3-2-4-12-24)28(32)21-31-17-7-8-18-31/h2-6,10-13,15-16,20,27-28H,7-9,14,17-19,21-22H2,1H3/t27-,28+/m1/s1
PubChem CID44448314
ChEMBLCHEMBL437216
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki158.49 nMPMID18420409ChEMBL

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