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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	5-amino-3-(3-aminopropyl)-1H-pyrazole-4-carbonitrile
Molecular formula	C7H11N5
IUPAC name	3-amino-5-(3-aminopropyl)-1H-pyrazole-4-carbonitrile
Molecular weight	165.2
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	-0.1
Synonyms	AC1M6GYP CTK7E7828 MLS000565238 ZINC3886766 3-amino-5-(3-aminopropyl)-1H-pyrazole-4-carbonitrile AJ-47237 F3285-1295 SMR000152478 5-Amino-3-[3-aminopropyl]-1H-pyrazole-4-carbonitrile KM2798 TC-127956 113513-27-2 AC1Q54EA DTXSID00368490 MolPort-002-465-232 AKOS002240552 HMS2455B16 ST24044324 890609-52-6 CHEMBL1432865 MCULE-5194844204 V8762 1H-Pyrazole-4-carbonitrile, 3-amino-5-(3-aminopropyl)- ACMC-209qyl EN300-06932 Oprea1_387194 5-amino-3-(3-aminopropyl)pyrazole-4-carbonitrile ANW-39211 J-516709 ST50192132 [ Show all ]
Inchi Key	AALOEZGCFHDEHM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H11N5/c8-3-1-2-6-5(4-9)7(10)12-11-6/h1-3,8H2,(H3,10,11,12)
PubChem CID	2398027
ChEMBL	CHEMBL1432865
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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