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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	BDBM37823
Molecular formula	C22H18N2O5
IUPAC name	5-(furan-2-yl)-4-(3-methoxybenzoyl)-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
Molecular weight	390.395
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	1.9
Synonyms	(4Z)-5-(furan-2-yl)-4-[(3-methoxyphenyl)-oxidanyl-methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione cid_5892636 (4Z)-5-(2-furanyl)-4-[hydroxy-(3-methoxyphenyl)methylidene]-1-(3-pyridinylmethyl)pyrrolidine-2,3-dione (4Z)-5-(2-furyl)-4-[hydroxy-(3-methoxyphenyl)methylene]-1-(3-pyridylmethyl)pyrrolidine-2,3-quinone
Inchi Key	BQNMLUSOHBPLEA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H18N2O5/c1-28-16-7-2-6-15(11-16)20(25)18-19(17-8-4-10-29-17)24(22(27)21(18)26)13-14-5-3-9-23-12-14/h2-12,18-19H,13H2,1H3
PubChem CID	91896350
ChEMBL	N/A
IUPHAR	N/A
BindingDB	37823
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<43700.0 nM	N/A	BindingDB

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