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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesHomo sapiens (Human)
GeneCHRM2
Synonymcholinergic receptor
AChR M2
M2 muscarinic acetylcholine receptor
M2 receptor
Chrm-2
[ Show all ]
DiseaseUrinary incontinence
Heart failure
Nausea; Addiction
Parkinson's disease
Peptic ulcer
[ Show all ]
Length466
Amino acid sequenceMNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP08172
Protein Data Bank5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8
GPCR-HGmod modelP08172
3D structure modelThis structure is from PDB ID 5zkc.
BioLiPBL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338
Therapeutic Target DatabaseT46185
ChEMBLCHEMBL211
IUPHAR14
DrugBankBE0000560

Ligand

NameOxotremorine
Molecular formulaC12H18N2O
IUPAC name1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidin-2-one
Molecular weight206.289
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP0.4
SynonymsCHEMBL7634
FT-0631303
KBio2_001928
KBioSS_001928
NCGC00015773-02
[ Show all ]
Inchi KeyRSDOPYMFZBJHRL-UHFFFAOYSA-N
Inchi IDInChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
PubChem CID4630
ChEMBLCHEMBL7634
IUPHAR302
BindingDB50004665
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5019.0 nMPMID7783150BindingDB,ChEMBL
Efficacy112.8 %PMID25765911ChEMBL
IC50400.0 nMPMID9438027BindingDB,ChEMBL
Ki17.0 nMPMID10891110BindingDB,ChEMBL
Ki235.0 nMPMID9454790PDSP,BindingDB
Ki251.189 - 10000.0 nMPMID9224827, PMID9454790IUPHAR
Ki323.59 nMPMID18182302ChEMBL
Ki660.0 nMPMID10891110BindingDB,ChEMBL
Ratio2.4 -Bioorg. Med. Chem. Lett., (1991) 1:3:147ChEMBL

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