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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Proteinase-activated receptor 1
Species	Homo sapiens (Human)
Gene	F2R
Synonym	Coagulation factor II receptor PAR-1 coagulation factor II (thrombin) receptor protease-activated receptor 1 Thrombin receptor PAR1 [ Show all ]
Disease	Thrombosis Restenosis Myocardial infarction Cancer Atherosclerosis Acute coronary syndrome [ Show all ]
Length	425
Amino acid sequence	MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
UniProt	P25116
Protein Data Bank	3vw7
GPCR-HGmod model	P25116
3D structure model	This structure is from PDB ID 3vw7.
BioLiP	BL0217099
Therapeutic Target Database	T36483
ChEMBL	CHEMBL3974
IUPHAR	347
DrugBank	BE0000928

Ligand

Name	2-methyl-N-[2-methyl-3-(propionylamino)phenyl]benzamide
Molecular formula	C18H20N2O2
IUPAC name	2-methyl-N-[2-methyl-3-(propanoylamino)phenyl]benzamide
Molecular weight	296.37
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	2.9
Synonyms	ARONIS24706 Z306561568 2-methyl-N-(2-methyl-3-propanamidophenyl)benzamide CHEMBL2047283 AKOS003571530 MolPort-006-360-487 BRD-K66789582-001-01-8 ZINC12977847 2-methyl-N-[2-methyl-3-(propanoylamino)phenyl]benzamide KS-000046NR AN-329/43465271 STL089553 1090450-34-2 MCULE-4302182553 [ Show all ]
Inchi Key	BQDYOVGQSJWZQQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H20N2O2/c1-4-17(21)19-15-10-7-11-16(13(15)3)20-18(22)14-9-6-5-8-12(14)2/h5-11H,4H2,1-3H3,(H,19,21)(H,20,22)
PubChem CID	25642843
ChEMBL	CHEMBL2047283
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	5.0 %	PMID22408714	ChEMBL

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