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GPCR

Name	Alpha-1A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1a
Synonym	alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor Alpha-1A adrenoceptor alpha-1A adrenergic receptor ADRA1C alpha 1C-adrenergic receptor alpha 1A-adrenoreceptor alpha 1A-adrenoceptor adrenergic receptor, alpha 1a adrenergic receptor alpha 1c adrenergic alpha 1c receptor ADRA1L1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProt	P43140
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL319
IUPHAR	22
DrugBank	N/A

Ligand

Name	mirtazapine
Molecular formula	C17H19N3
IUPAC name	5-methyl-2,5,19-triazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene
Molecular weight	265.36
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.3
Synonyms	Remirta (TN) Smilon Mirtazapine [USAN:USP:INN:BAN] SW197784-4 Mirtazen (TN) VA11306 Mirtel (TN) Zispin (TN) Mizapin Sol (TN) NCGC00025346-01 Organon brand of mirtazapine PYR432 Remergon Mirtawin (TN) CTK8B3409 DSSTox_RID_76979 FT-0601544 337M675 HMS3370B05 61337-67-5 J10458 AC1L1HND M-130 AN-8319 methylBLAH Azamianserin Mirta (TN) BRD-A64977602-001-04-3 Mirtalich (TN) Mirtaril (TN) Mirtazapin RONZAEMNMFQXRA-UHFFFAOYSA-N Mirtazapine 1.0 mg/ml in Methanol SR-01000597530 Mirtazapine, European Pharmacopoeia (EP) Reference Standard Tazapin (TN) Mirtazepine Z2327131613 Mirzalux (TN) Zuleptan (TN) MLS001424294 Norset Pharmasole (TN) Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl- 85650-52-8 Remeron (TN) Mirtasole (TN) EN300-49851 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine GTPL7241 5-methyl-2,5,19-triazatetracyclo[13.4.0.0?,?.0?,??]nonadeca-1(19),8,10,12,15,17-hexaene HMS3657M13 85650-52-8 KS-1086 AKOS005530681 ME-2040 Arintapina (TN) Miralix (TN) BCP22244 Mirtachem (TN) CAS-61337-67-5 Mirtamerck (TN) CM0152 Remeron, Avanza, Zispin Mirtazapina (TN) SC-16155 Mirtazapine [USAN:BAN:INN] ST24048108 Mirtazapinum [INN-Latin] Tox21_110965 Mirtazon (TN) Zismirt (TN) Mitrazen (TN) Mundogen brand of mirtazapine ORG 3770 Promyrtil (TN) Remergil Mirtatifi (TN) DSSTox_CID_3325 (14bR)-2-methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine Finpharma (TN) 2-Methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine HMS2233K03 I01-1882 AB2000422 LS-127703 Amirel (TN) Mepirzapine Axit Miro (TN) Bexzis (TN) Mirtagamma (TN) Celltech brand of mirtazapine Mirtapin(TN) CPD000466347 Rexer Mirtazapine (JAN/USAN/INN) SMR000466347 Mirtazapine, 98% Tarzapine (TN) Mirtazep (TN) Valdren (TN) Mirtoral (TN) Zispin SolTab (TN) MLS000759460 NCGC00025346-02 PDSP1_001529 Pyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl- Remergon (TN) Mirtaz D00563 DTXSID0023325 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine FT-0628951 5-methyl-2,5,19-triazatetracyclo[13.4.0.0(2),.0,(1)(3)]nonadeca-1(19),8,10,12,15,17-hexaene HMS3374J01 K532 AC1Q3ZYM M2151 ANW-42478 MFCD00865427 BBL009962 Mirtabene C07570 Mirtalphagen (TN) CHEMBL654 Mirtaron (TN) Mirtazapin (TN) s2016 Mirtazapine for system suitability, European Pharmacopoeia (EP) Reference Standard SR-01000597530-1 Mirtazapine, United States Pharmacopeia (USP) Reference Standard Tazascope (TN) Mirtazipine Zapex (TN) Mirzaten (TN) MLS006011449 Norset (TN) Pharmazepine (TN) Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, (.+/-.)- Remeron SolTab Mirtastad (TN) DB00370 (+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-triaza-tribenzo[a,c,e]cycloheptene Esprital (TN) 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine. Hexazipin (TN) 5-methyl-2,5,19-triazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene HMS3713P13 AB0014270 L001294 Alphamirt (TN) Medizapin (TN) Avanza Mirap (TN) BCP9000930 Mirtacur (TN) CCG-101154 Mirtapax (TN) Combar (TN) Remeron;Avanza Mirtazapina [INN-Spanish] SCHEMBL35408 Mirtazapine [USAN:INN:BAN] STK711107 Mirtazelon (TN) TR-026749 Mirtazza (TN) Zispin Mizapin (TN) NC00404 Org-3770 PubChem22104 Remergil (TN) Mirtatsapiini (TN) CS-2398 DSSTox_GSID_23325 (N-methyl-11C)mirtazapine Finscope (TN) 2-methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-triaza-tribenzo[a,c,e]cycloheptene HMS3268F21 6-Azamianserin I06-0606 AC-15480 LS-185067 AN-35645 Mepirzepine Axit (TN) Miron (TN) BRD-A64977602-001-01-9 Mirtal (TN) CHEBI:6950 Mirtaratio (TN) Mirtaz (TN) Rexer (TN) Mirtazapine (Remeron, Avanza) SolTab (TN) Mirtazapine, >=98% (HPLC) Tazamel (TN) Mirtazepin (TN) Vastat (TN) Mirzagen (TN) Zistap. (TN) MLS001076676 NE42580 PDSP2_001513 Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl- Remeron D05ZIK EINECS 288-060-6 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c](2)benzazepine Genamirt (TN) 5-methyl-2,5,19-triazatetracyclo[13.4.0.0;{2,7}.0;{8,13}]nonadeca-1(19),8(13),9,11,15,17-hexaene HMS3394H03 82601-27-2 KS-000010W5 Afloyan (TN) MCULE-1174883554 Arintapin (TN) Mianserin, 6-Aza-; ORG 3770 BCP14560 Mirtabene (TN) Calixta (TN) Mirtamed (TN) Ciblex (TN) Mirtascope (TN) Mirtazapina SAM001246659 Mirtazapine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material SR-01000597530-4 Mirtazapinum Tirzamed (TN) Mirtazon Zicomber (TN) Mirzaten Q-Tab (TN) MolPort-003-849-233 Noxibel (TN) Promyrtil Reflex (TN) Remeron SolTab (TN) Mirtastada (TN) Divaril (TN) (1)-1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine Finmirtaza (TN) 2-methyl-1,2,3,4,10,14b-hexahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepine HMS2052H03 5-methyl-2,5,19-triazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(19),8(13),9,11,15,17-hexaene HY-B0352 AB00698265_08 Loxozapin (TN) Alphazagen (TN) Mepirzapin Avanza (TN) Mirazep (TN) BDBM50115644 Mirtadepi (TN) CCG-220556 Mirtapharm (TN) Comenter (TN) [ Show all ]
Inchi Key	RONZAEMNMFQXRA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
PubChem CID	4205
ChEMBL	CHEMBL654
IUPHAR	7241
BindingDB	50115644
DrugBank	DB00370
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	316.23 nM	PMID3419539	BindingDB
Ki	371.54 nM	PMID3419539	BindingDB
Ki	1513.56 nM	PMID3419539	BindingDB

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