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Name | Neuropeptide S receptor |
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Species | Homo sapiens (Human) |
Gene | NPSR1 |
Synonym | G-protein coupled receptor for asthma susceptibility vasopressin receptor-related receptor 1 G protein-coupled receptor 154 PGR14 NPS receptor [ Show all ] |
Disease | Neurological disease |
Length | 371 |
Amino acid sequence | MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI |
UniProt | Q6W5P4 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q6W5P4 |
3D structure model | This predicted structure model is from GPCR-EXP Q6W5P4. |
BioLiP | N/A |
Therapeutic Target Database | T20958 |
ChEMBL | CHEMBL5162 |
IUPHAR | 302 |
DrugBank | BE0000948 |
Name | SMR000151229 |
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Molecular formula | C26H32N4O2 |
IUPAC name | N-[[3-[(2,3-dihydroindole-1-carbonylamino)methyl]cyclohexyl]methyl]-2,3-dihydroindole-1-carboxamide |
Molecular weight | 432.568 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 2 |
XlogP | 4.0 |
Synonyms | MolPort-004-029-970 HMS2395N15 AC1N1MAR MLS000572131 CHEMBL1308130 [ Show all ] |
Inchi Key | ADQOQDWLPPQSFQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H32N4O2/c31-25(29-14-12-21-8-1-3-10-23(21)29)27-17-19-6-5-7-20(16-19)18-28-26(32)30-15-13-22-9-2-4-11-24(22)30/h1-4,8-11,19-20H,5-7,12-18H2,(H,27,31)(H,28,32) |
PubChem CID | 4032625 |
ChEMBL | CHEMBL1308130 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Potency | 10000.0 nM | PubChem BioAssay data set | ChEMBL |
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