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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Beta-2 adrenergic receptor
Species	Cavia porcellus (Guinea pig)
Gene	Adrb2
Synonym	Beta-2 adrenoceptor Beta-2 adrenoreceptor
Disease	N/A for non-human GPCRs
Length	418
Amino acid sequence	MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
UniProt	Q8K4Z4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5414
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL7278
Molecular formula	C11H15NO3
IUPAC name	4-(3-hydroxypiperidin-3-yl)benzene-1,2-diol
Molecular weight	209.245
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	0.2
Synonyms	BDBM50000496 100112-61-6 CTK8G4032 1,2-Benzenediol, 4-(3-hydroxy-3-piperidinyl)- 3-(3,4-Dihydroxyphenyl)piperidin-3-ol D0T5KJ AKOS022649735 1,2-benzenediol,4-(3-hydroxy-3-piperidinyl)- 4-(3-Hydroxy-piperidin-3-yl)-benzene-1,2-diol KB-148878 [ Show all ]
Inchi Key	REBGJGKBMBFBHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H15NO3/c13-9-3-2-8(6-10(9)14)11(15)4-1-5-12-7-11/h2-3,6,12-15H,1,4-5,7H2
PubChem CID	11820398
ChEMBL	CHEMBL7278
IUPHAR	N/A
BindingDB	50000496
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Intrinsic activity	0.77 -	PMID1313109	ChEMBL
pD2	4.44 -	PMID1313109	ChEMBL

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