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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	SMR000028501
Molecular formula	C14H10FN3O
IUPAC name	N-(1H-benzimidazol-2-yl)-4-fluorobenzamide
Molecular weight	255.252
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	2.9
Synonyms	STK470745 61810-47-7 HMS1377A08 N-(1H-benzimidazol-2-yl)-4-fluoro-benzamide N-benzimidazol-2-yl(4-fluorophenyl)carboxamide BDBM39107 MLS000092864 SR-01000098433-1 ChemDiv2_002824 N-(1H-1,3-benzodiazol-2-yl)-4-fluorobenzamide Z27666156 AC1M9I4Q HMS2448E24 N-(1H-benzimidazol-2-yl)-4-fluorobenzamide MolPort-002-243-440 ST50926874 cid_2583534 N-(1H-benzimidazol-2-yl)-4-fluoranyl-benzamide ZINC5033953 AKOS003241307 MCULE-3301322061 N-1,3-dihydro-2H-benzimidazol-2-ylidene-4-fluorobenzamide SR-01000098433 CHEMBL1347477 N-(1H-1,3-benzimidazol-2-yl)-4-fluorobenzamide [ Show all ]
Inchi Key	BOYRIPHPOSSJNS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H10FN3O/c15-10-7-5-9(6-8-10)13(19)18-14-16-11-3-1-2-4-12(11)17-14/h1-8H,(H2,16,17,18,19)
PubChem CID	2583534
ChEMBL	CHEMBL1347477
IUPHAR	N/A
BindingDB	39107
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	6309.6 nM	PubChem BioAssay data set	ChEMBL

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