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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2b
Synonym	ADRA2L1 alpha2B-adrenoceptor alpha2B alpha2-C2 alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor Adra-2b adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 alpha-2B adrenergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	453
Amino acid sequence	MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProt	P19328
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL266
IUPHAR	26
DrugBank	N/A

Ligand

Name	CHEMBL89030
Molecular formula	C24H34N4O2
IUPAC name	2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-N,N,4-trimethylbenzamide
Molecular weight	410.562
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.2
Synonyms	BDBM50408241
Inchi Key	RCDCEIAISULOCZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H34N4O2/c1-19-10-11-20(24(29)26(2)3)21(18-19)25-12-7-13-27-14-16-28(17-15-27)22-8-5-6-9-23(22)30-4/h5-6,8-11,18,25H,7,12-17H2,1-4H3
PubChem CID	44323795
ChEMBL	CHEMBL89030
IUPHAR	N/A
BindingDB	50408241
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	316.0 nM	PMID9276013	BindingDB
Log Ki	6.5 uM	PMID9276013	ChEMBL

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