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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	SR-02000000358
Molecular formula	C21H20N2O3
IUPAC name	5-cyclopropyl-4-(4-methoxyphenoxy)-2-(4-methylphenyl)pyridazin-3-one
Molecular weight	348.402
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.0
Synonyms	SR-02000000358-1 5-cyclopropyl-4-(4-methoxyphenoxy)-2-(4-methylphenyl)pyridazin-3-one BDBM75890 cid_46172939 5-cyclopropyl-4-(4-methoxyphenoxy)-2-(p-tolyl)pyridazin-3-one 5-cyclopropyl-4-(4-methoxyphenoxy)-2-(4-methylphenyl)-3-pyridazinone CHEMBL1728621 [ Show all ]
Inchi Key	BOSONUOCNBJILM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H20N2O3/c1-14-3-7-16(8-4-14)23-21(24)20(19(13-22-23)15-5-6-15)26-18-11-9-17(25-2)10-12-18/h3-4,7-13,15H,5-6H2,1-2H3
PubChem CID	46172939
ChEMBL	CHEMBL1728621
IUPHAR	N/A
BindingDB	75890
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5400.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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