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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	serotonin
Molecular formula	C10H12N2O
IUPAC name	3-(2-aminoethyl)-1H-indol-5-ol
Molecular weight	176.219
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.2
Synonyms	KBio2_005040 5-Hydroxy-3-(beta-aminoethyl)indole KBioSS_000452 50-67-9 NCGC00015525-01 AN-41571 NCGC00015525-09 Bio1_000939 PDSP2_001496 BRN 0143524 Serotonin, analytical standard CH-132 Thrombocytin, 3-(\|A-Aminoethyl)-5-hydroxyindole, Thrombotonin GTPL5 2-imino-1-methylimidazolidin-4-one; 3-(2-aminoethyl)-1H-indol-5-ol; bis(sulfuric acid) I14-1899 333DO1RDJY KBio3_000843 5-Hydroxyltryptamine Lopac-H-9523 AC1L1JTO NCGC00015525-04 API0006544 NCGC00142449-03 Bio2_000876 Prestwick2_000481 C-06146 SPBio_002262 CHEMBL39 Tryptamine, 5-hydroxy- EINECS 200-058-9 Hippophaine 3-(2-Aminoethyl)-1H-indol-5-ol K-9367 5-HT 5-Hydroxy-3-(.beta.-aminoethyl)indole KBioGR_000452 5-Hydroxytryptamine, 5-HT, Enteramine MCULE-8788459983 AKOS001484724 NCGC00015525-07 BDBM10755 Oprea1_712368 BPBio1_000377 SCHEMBL1495 CC-21879 Substanz DS D0F6CD FCH832159 1H-Indol-5-ol, 3-(2-aminoethyl)- HMS1990H13 3-(b-Aminoethyl)-5-hydroxyindole KBio2_002472 KBio2_005588 5-hydroxy-tryptamine KBioSS_002479 6996AB NCGC00015525-02 Antemoqua NCGC00142449-01 Bio1_001428 Prestwick0_000481 BSPBio_000341 Serotonine CHEBI:28790 Thrombotonin Ds substance H-8000 3-(.beta.-Aminoethyl)-5-hydroxyindole IDI1_002151 5-Hta KBio3_000844 5-Hydroxytriptamine Lopac0_000607 AC1Q54C0 NCGC00015525-05 AX8011985 NCGC00142449-04 Biomol-NT_000083 Prestwick3_000481 C00780 STK503758 cMAP_000059 UNII-333DO1RDJY Enteramin HMS1362H13 3-(2-Aminoethyl)-1H-indol-5-ol # KB-177045 5-Hydroxy-3-(b-aminoethyl)indole KBioGR_002472 5-Hydroxytryptamine, free base MolPort-001-779-633 ALBB-006183 NCGC00015525-08 Bio1_000450 PDSP1_001512 BPBio1_001079 CCG-204696 Thrombocytin DB-051820 FT-0631212 1H-Indol-5-ol,3-(2-aminoethyl)- HMS3403H13 3-(beta-Aminoethyl)-5-hydroxyindole KBio2_003020 KBio2_007608 5-hydroxyl tryptamine L000078 6F7FD5B4-A558-45F0-A20A-2D068A3EFE6A NCGC00015525-03 Antemovis NCGC00142449-02 Bio2_000396 Prestwick1_000481 BSPBio_001112 SMP1_000272 TR-018115 DTXSID8075330 Hippophain 3-(2-Amino-ethyl)-1H-indol-5-ol Indol-5-ol, 3-(2-aminoethyl)- 5-22-12-00016 (Beilstein Handbook Reference) 5-hydroxy tryptamine creatinine disulfate KBio3_002950 5-HYDROXYTRYPTAMINE LS-83647 AJ-09556 NCGC00015525-06 BCBcMAP01_000198 NCGC00142449-05 bmse000757 QZAYGJVTTNCVMB-UHFFFAOYSA-N CAS-153-98-0 Substance DS CTK4J2994 ZINC57058 Enteramine 14C-5-hydroxy tryptamine creatinine disulfate HMS1792H13 3-(2-Aminoethyl)indol-5-ol KBio2_000452 [ Show all ]
Inchi Key	QZAYGJVTTNCVMB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
PubChem CID	5202
ChEMBL	CHEMBL39
IUPHAR	5
BindingDB	10755
DrugBank	DB08839
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	52.0 %	PMID23792350	ChEMBL
EC50	55.8 nM	PMID12954071	BindingDB,ChEMBL
EC50	57.9 nM	PMID16392816	ChEMBL
EC50	58.0 nM	PMID16392816	BindingDB
EC50	351.0 nM	PMID12954071	BindingDB,ChEMBL
Emax	99.0 %	PMID16392816	ChEMBL
IC50	0.9 nM	PMID12954071	BindingDB,ChEMBL
IC50	0.94 nM	PMID16392816	ChEMBL
IC50	0.94 nM	PMID16392816	BindingDB
IC50	600.0 nM	PMID23792350	ChEMBL
IC50	2350.0 nM	PMID9357534	BindingDB,ChEMBL
IC50	13000.0 nM	PMID23792350	ChEMBL
IC50	30600.0 nM	PMID23792350	ChEMBL
Ki	0.3 nM	PMID12954071	BindingDB,ChEMBL
Ki	1.99 nM	PMID7984267	BindingDB
Ki	3.0 nM	PMID2795135	BindingDB
Ki	5.75 nM	PMID7984267	BindingDB
Ki	83.0 nM	PMID6645787	BindingDB
Ki	96.0 nM	PMID9686407	BindingDB
Ki	120.22 nM	PMID9225287	BindingDB
Ki	125.89 nM	PMID7582481	BindingDB
Ki	251.18 nM	PMID7984267	BindingDB
Ki	270.0 nM	PMID6645787	BindingDB
Ki	316.228 - 1000.0 nM	PMID11040033, PMID11104741, PMID9655845	IUPHAR
Ki	478.63 nM	PMID7984267	BindingDB
Ki	707.94 nM	PMID7984267	BindingDB
Ki	1258.0 nM	PMID19425598, PMID19831400	BindingDB,ChEMBL
Ki	1258.93 nM	PMID10543880	ChEMBL
Ki	2955.0 nM	PMID8510008	BindingDB

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