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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Homo sapiens (Human)
Gene	CHRM2
Synonym	cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 cholinergic receptor, muscarinic 2, cardiac cholinergic receptor, muscarinic 2 [ Show all ]
Disease	Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer Stabilize muscle contractions Unspecified Cardiovascular disorder Asthma Alzheimer disease [ Show all ]
Length	466
Amino acid sequence	MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P08172
Protein Data Bank	5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8
GPCR-HGmod model	P08172
3D structure model	This structure is from PDB ID 5zkc.
BioLiP	BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338
Therapeutic Target Database	T46185
ChEMBL	CHEMBL211
IUPHAR	14
DrugBank	BE0000560

Ligand

Name	hexahydrosiladifenidol
Molecular formula	C20H33NOSi
IUPAC name	cyclohexyl-hydroxy-phenyl-(3-piperidin-1-ylpropyl)silane
Molecular weight	331.575
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	None
Synonyms	cyclohexylphenyl(3-piperidino-propyl)silanol HHSiD Silanol, cyclohexylphenyl(3-(1-piperidinyl)propyl)- BDBM81799 GTPL310 MCULE-7618291320 CHEMBL3545990 cyclohexyl(phenyl)[3-(piperidin-1-yl)propyl]silanol hexahydrosiladiphenidol PDSP1_000646 AC1Q59YI D07LDP L000721 STK549888 C20H33NOSi Hexahydro-sila-diphenidol MolPort-002-586-096 98299-40-2 CTK5H9810 cyclohexyl-hydroxy-phenyl-(3-piperidin-1-ylpropyl)silane Hhsi-difenidol PDSP2_000641 AKOS001683522 GNF-Pf-5565 LS-178373 ZINC169857732 CAS_98299-40-2 cyclohexyl(phenyl)(3-piperidin-1-ylpropyl)silanol NSC_3602 AC1L1GAQ [ Show all ]
Inchi Key	QTBCATBNRIYMPB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H33NOSi/c22-23(19-11-4-1-5-12-19,20-13-6-2-7-14-20)18-10-17-21-15-8-3-9-16-21/h1,4-5,11-12,20,22H,2-3,6-10,13-18H2
PubChem CID	3602
ChEMBL	N/A
IUPHAR	310
BindingDB	81799
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Ki	153.0 nM	PMID9454790	PDSP,BindingDB
Ki	158.489 - 251.189 nM	PMID8759038, PMID2704370, PMID9454790	IUPHAR
Ki	249.0 nM	PMID2704370	PDSP,BindingDB

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