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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Rattus norvegicus (Rat)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P10980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL309
IUPHAR	14
DrugBank	N/A

Ligand

Name	hexahydrosiladifenidol
Molecular formula	C20H33NOSi
IUPAC name	cyclohexyl-hydroxy-phenyl-(3-piperidin-1-ylpropyl)silane
Molecular weight	331.575
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	None
Synonyms	AC1L1GAQ cyclohexyl(phenyl)(3-piperidin-1-ylpropyl)silanol NSC_3602 BDBM81799 cyclohexylphenyl(3-piperidino-propyl)silanol HHSiD Silanol, cyclohexylphenyl(3-(1-piperidinyl)propyl)- CHEMBL3545990 GTPL310 MCULE-7618291320 AC1Q59YI cyclohexyl(phenyl)[3-(piperidin-1-yl)propyl]silanol hexahydrosiladiphenidol PDSP1_000646 C20H33NOSi D07LDP L000721 STK549888 98299-40-2 CTK5H9810 Hexahydro-sila-diphenidol MolPort-002-586-096 AKOS001683522 cyclohexyl-hydroxy-phenyl-(3-piperidin-1-ylpropyl)silane Hhsi-difenidol PDSP2_000641 CAS_98299-40-2 GNF-Pf-5565 LS-178373 ZINC169857732 [ Show all ]
Inchi Key	QTBCATBNRIYMPB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H33NOSi/c22-23(19-11-4-1-5-12-19,20-13-6-2-7-14-20)18-10-17-21-15-8-3-9-16-21/h1,4-5,11-12,20,22H,2-3,6-10,13-18H2
PubChem CID	3602
ChEMBL	N/A
IUPHAR	310
BindingDB	81799
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Ki	12.4 nM	PMID2704370	BindingDB
Ki	30.4 nM	PMID2005579	BindingDB
Ki	49.1 nM	PMID2005579	BindingDB
Ki	50.2 nM	PMID2547939	BindingDB
Ki	120.23 nM	PMID2250662	BindingDB
Ki	158.489 - 199.526 nM	PMID1325587, PMID9454790	IUPHAR
Ki	162.0 nM	PMID2005579	BindingDB
Ki	174.0 nM	PMID9454790	BindingDB
Ki	300.0 nM	PMID2385234	BindingDB
Ki	452.0 nM	PMID2005579	BindingDB

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